The association between the APE1 Asp148Glu polymorphism and breast cancer susceptibility: a meta-analysis based on case–control studies

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• 作者：Zhiyong Zhao (1) (2)
  Chuan Liu (3)
  Yong Zeng (4)
  Lei Gu (3)
  Mingzhen Ying (3)
  Ning Wang (3)
  Bin Hao (2)
  Huiyan Yao (2)
  Changqing Su (4)
  Yajie Wang (3)
  Yuchen Ma (2)
  
• 关键词：APE1 Asp148Glu ; Breast cancer ; Susceptibilitym ; Meta ; analysis
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：35
• 期：5
• 页码：4727-4734
• 全文大小：
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• 作者单位：Zhiyong Zhao (1) (2)
  Chuan Liu (3)
  Yong Zeng (4)
  Lei Gu (3)
  Mingzhen Ying (3)
  Ning Wang (3)
  Bin Hao (2)
  Huiyan Yao (2)
  Changqing Su (4)
  Yajie Wang (3)
  Yuchen Ma (2)
  
  1. Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, People’s Republic of China
  2. Department of rehabilitation, Chinese PLA 252 Hospital, Baoding, People’s Republic of China
  3. Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, People’s Republic of China
  4. Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai, People’s Republic of China
  
• ISSN：1423-0380

文摘

Published data regarding the association between the APE1 Asp148Glu polymorphism and breast cancer susceptibility showed inconclusive results. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, Elsevier, and Springer for relevant articles published before December 10. 2013. The strength of association between APE1 Asp148Glu polymorphism and breast cancer susceptibility was assessed by odds ratio (OR) with the corresponding 95?% confidence interval (95?% CI) using the software Stata (version 10.0). A total of 7 case–control studies including 3,460 cases and 3,909 controls were included for analysis. Overall, no significant associations were found between the APE1 Asp148Glu polymorphism and breast cancer susceptibility for GG vs TT (OR--.00, 95?% CI--.87-.14); TG vs TT (OR--.06, 95?% CI--.95-.18); the dominant model GG-?TG vs TT (OR--.04, 95?% CI--.94-.16) and the recessive model GG vs TG-?TT (OR--.99, 95?% CI--.88-.11). In subgroup analysis, a significant association was found for TG vs TT in Asian subgroup (OR--.17, 95?% CI--.00?~-.36) and in population-based subgroup (OR--.18, 95?% CI--.00?~-.38). This meta-analysis suggested that the APE1 Asp148Glu polymorphism was a risk factor for breast cancer susceptibility among Asian population.