Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck
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- 作者：Dirk Rades ; Stefan Huttenlocher ; Nina D Seibold ; Maximilian P Gebhard…
- 关键词：Head ; and ; neck cancer ; Postoperative treatment ; Nuclear factor kappa B ; p65 (RelA) ; Outcomes
- 刊名：BMC Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：848 KB
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- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background This study investigated the prognostic role of nuclear expression of p65 in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) receiving post-operative radio(chemo)therapy. Methods Nuclear p65-expression (H-score ?0 versus >50) plus twelve characteristics were analyzed in 151 patients for overall survival (OS), metastases-free survival (MFS) and loco-regional control (LRC). Additional characteristics included age, gender, Karnofsky performance score (KPS), pre-radiotherapy hemoglobin levels, tumor site, histological grading, human papilloma virus (HPV)-status, T-classification, N-classification, American Joint Committee on Cancer (AJCC)-stage, extent of resection and concurrent chemotherapy. Univariate analyses were performed with Kaplan-Meier method and log-rank test, multivariate analyses with Cox proportional hazards model. Results On univariate analyses, p65-expression had a significant impact on OS (p--.001) and LRC (p--.001) but not on MFS (p--.29). On multivariate analysis, KPS ?0 (risk ratio [RR] 2.23; p--.012), HPV-positivity (RR 5.83; p--.020), T1-T2 (RR 1.38; p--.048), N0-N2a (RR 2.72; p--.005) and complete resection (RR 2.02; p--.049) were positively associated with OS; p65-negativity achieved borderline significance (RR 3.02; p--.052). Better MFS was associated with KPS ?0 (RR 2.49; p--.015), T1-T2 (RR: 1.74; p--.005), N0-N2a (RR: 6.22; p--.001) and complete resection (RR 3.43; p--.003). Positive associations with LRC were found for p65-negativity (RR 5.06; p--.008), T1-T2 (RR: 1.49; p--.022), N0-N2a (RR: 2.97; p--.004) and favorable tumor site (RR 1.28; p--.025). Conclusions P65-negativity was significantly associated with improved LRC and achieved borderline significance with respect to improved OS. Thus, p65-expression may be an additional target for novel agents in the treatment of locally advanced SCCHN.