Injectable Hydrogel Composite Based Gelatin-PEG and Biphasic Calcium Phosphate Nanoparticles for Bone Regeneration

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• 作者：Thuy Duong Van ; Ngoc Quyen Tran ; Dai Hai Nguyen…
• 关键词：Gelatin ; BCP ; hydrogel composite ; injectable hydrogel
• 刊名：Journal of Electronic Materials
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：45
• 期：5
• 页码：2415-2422
• 全文大小：1,256 KB
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• 作者单位：Thuy Duong Van (1) (2)
  Ngoc Quyen Tran (1) (2)
  Dai Hai Nguyen (2)
  Cuu Khoa Nguyen (2)
  Dai Lam Tran (1) (3)
  Phuong Thi Nguyen (2)
  
  1. Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam
  2. Institute of Applied Material Science, Vietnam Academy of Science and Technology (VAST), Ho Chi Minh City, Vietnam
  3. Graduate University of Science and Technology, Vietnam Academy of Science and Technology (GUST-VAST), Cau Giay, Hanoi, Vietnam
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Optical and Electronic Materials
  Characterization and Evaluation Materials
  Electronics, Microelectronics and Instrumentation
  Solid State Physics and Spectroscopy
  
• 出版者：Springer Boston
• ISSN：1543-186X

文摘

Gelatin hydrogels have recently attracted much attention for tissue regeneration because of their biocompatibility. In this study, we introduce poly-ethylene glycol (PEG)—grafted gelatin containing tyramine moieties which have been utilized for in situ enzyme-mediated hydrogel preparation. The hydrogel can be used to load nanoparticles of biphasic calcium phosphate, a mixture of hydroxyapatite and β-tricalcium phosphate, and forming injectable bio-composites. Proton nuclear magnetic resonance (1H NMR) spectra indicated that tyramine-functionalized polyethylene glycol-nitrophenyl carbonate ester was conjugated to the gelatin. The hydrogel composite was rapidly formed in situ (within a few seconds) in the presence of horseradish peroxidase and hydrogen peroxide. In vitro experiments with bio-mineralization on the hydrogel composite surfaces was well-observed after 2 weeks soaking in simulated body fluid solution. The obtained results indicated that the hydrogel composite could be a potential injectable material for bone regeneration.