A proliferation saturation index to predict radiation response and personalize radiotherapy fractionation

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• 作者：Sotiris Prokopiou ; Eduardo G. Moros ; Jan Poleszczuk ; Jimmy Caudell…
• 关键词：Proliferation saturation index ; Personalized radiotherapy ; Logistic tumor growth ; Mathematical model ; Hyperfractionation
• 刊名：Radiation Oncology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：1,377 KB
• 刊物主题：Oncology; Radiotherapy;
• 出版者：BioMed Central
• ISSN：1748-717X

文摘

Background Although altered protocols that challenge conventional radiation fractionation have been tested in prospective clinical trials, we still have limited understanding of how to select the most appropriate fractionation schedule for individual patients. Currently, the prescription of definitive radiotherapy is based on the primary site and stage, without regard to patient-specific tumor or host factors that may influence outcome. We hypothesize that the proportion of radiosensitive proliferating cells is dependent on the saturation of the tumor carrying capacity. This may serve as a prognostic factor for personalized radiotherapy (RT) fractionation.