Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study

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• 作者：Gowhar Ali (1)
  Fazal Subhan (1)
  Nazar Ul Islam (2) (3)
  Nasir Ullah (2)
  Muhammad Shahid (1)
  Sami Ullah (1)
  Ihsan Ullah (1)
  Rehmat Shah (1)
  Ikhtiar Khan (2)
  Robert D. E. Sewell (4)
  Ghulam Abbas (5)
  
• 关键词：[1 ; (2 ; hydroxybenzyl)piperidiniumchloride] ; [4 ; carbamoyl ; 1 ; (2 ; hydroxybenzyl)piperidinium chloride] ; Acetylsalicylic acid ; Ulcerogenicity ; Gastric juice analysis ; Histology
• 刊名：Archives of Pharmacal Research
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：37
• 期：7
• 页码：916-926
• 全文大小：1,880 KB
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• 作者单位：Gowhar Ali (1)
  Fazal Subhan (1)
  Nazar Ul Islam (2) (3)
  Nasir Ullah (2)
  Muhammad Shahid (1)
  Sami Ullah (1)
  Ihsan Ullah (1)
  Rehmat Shah (1)
  Ikhtiar Khan (2)
  Robert D. E. Sewell (4)
  Ghulam Abbas (5)
  
  1. Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan
  2. Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120, Pakistan
  3. Sarhad University of Sciences and Information Technology, Peshawar, 25000, Pakistan
  4. Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Ave., Cardiff, CF10 3NB, UK
  5. Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan
  
• ISSN：1976-3786

文摘

The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6?days: group I saline control; group II, standard (aspirin) treatment group [150?mg/kg of body weight]; group III, test (compound I) treatment group [100, 150?mg/kg]; group IV, test (compound II) treatment group [100, 150?mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150?mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100?mg/kg] and (II) [100, 150?mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.