N-glycosylation profile of the protective chimeric antibody ch14D5a against tick-borne encephalitis virus
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- 作者：I. K. Baykov ; A. L. Matveev ; I. G. Kondratov…
- 关键词：immunoglobulins ; glycosylation ; tick ; borne encephalitis ; mass spectrometry
- 刊名：Russian Journal of Bioorganic Chemistry
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：43
- 期：1
- 页码：71-75
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biochemistry, general; Bioorganic Chemistry; Organic Chemistry; Biomedicine general;
- 出版者：Pleiades Publishing
- ISSN：1608-330X
- 卷排序：43
文摘
The glycosylation profile of the chimeric antibody ch14D5a against the tick-borne encephalitis virus has been analyzed. It has been found that the ch14D5a antibody is completely N-glycosylated at the asparagine 297 residue of both heavy chains, and the major glycoforms correspond supposedly to glycoforms G0F, G1F, and G2F, which are most typical for human immunoglobulins IgG and for antibodies secreted by CHO cells.