Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis

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• 作者：Michael E. Johnson ; Andrew V. Grassetti ; Jaclyn N. Taroni…
• 关键词：Systemic sclerosis ; Scleroderma ; Autoantibody ; RNA processing bodies ; Stress granules
• 刊名：Arthritis Research & Therapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：1
• 全文大小：1,438 KB
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• 作者单位：Michael E. Johnson (1)
  Andrew V. Grassetti (1)
  Jaclyn N. Taroni (1)
  Shawn M. Lyons (2)
  Devin Schweppe (1)
  Jessica K. Gordon (3)
  Robert F. Spiera (3)
  Robert Lafyatis (4)
  Paul J. Anderson (2)
  Scott A. Gerber (1)
  Michael L. Whitfield (1) (5)
  
  1. Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
  2. Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, USA
  3. Department of Rheumatology, Hospital for Special Surgery, New York, NY, USA
  4. Boston University School of Medicine, Boston, MA, USA
  5. Dartmouth Medical School, Hinman Box 7400, Hanover, NH, 03755, USA
  
• 刊物主题：Rheumatology; Orthopedics;
• 出版者：BioMed Central
• ISSN：1478-6354

文摘

Background Autoantibody profiles represent important patient stratification markers in systemic sclerosis (SSc). Here, we performed serum-immunoprecipitations with patient antibodies followed by mass spectrometry (LC-MS/MS) to obtain an unbiased view of all possible autoantibody targets and their associated molecular complexes recognized by SSc.