Biomarkers related to immunosenescence: relationships with therapy and survival in lung cancer patients

详细信息    查看全文

• 作者：Danay Saavedra ; Beatriz García ; Patricia Lorenzo-Luaces…
• 关键词：Immunosenescence ; Immunosenescence markers ; Non ; small cell lung cancer ; Cancer vaccine
• 刊名：Cancer Immunology, Immunotherapy
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：65
• 期：1
• 页码：37-45
• 全文大小：1,234 KB
• 参考文献：1.Fulop T, Larbi A, Kotb R, Pawelec G (2013) Immunology of aging and cancer development. Interdiscip Top Gerontol 38:38–48. doi:10.​1159/​000343599 PubMed CrossRef
  2.Fulop T, Larbi A, Kotb R, de Angelis F, Pawelec G (2011) Aging, immunity, and cancer. Discov Med 11:537–550PubMed
  3.Lang PO, Govind S, Aspinall R (2013) Reversing T cell immunosenescence: why, who, and how. Age 35:609–620. doi:10.​1007/​s11357-012-9393-y PubMed PubMedCentral CrossRef
  4.Pawelec G (2014) Immunosenenescence: role of cytomegalovirus. Exp Gerontol 54:1–5. doi:10.​1016/​j.​exger.​2013.​11.​010 PubMed CrossRef
  5.Pawelec G (2012) Hallmarks of human “immunosenescence”: adaptation or dysregulation? Immun Ageing 9:15. doi:10.​1186/​1742-4933-9-15 PubMed PubMedCentral CrossRef
  6.Falci C, Gianesin K, Sergi G, Giunco S, De Ronch I, Valpione S et al (2013) Immune senescence and cancer in elderly patients: results from an exploratory study. Exp Gerontol 48:1436–1442. doi:10.​1016/​j.​exger.​2013.​09.​011 PubMed CrossRef
  7.Mazzola P, Radhi S, Mirandola L, Annoni G, Jenkins M, Cobos E, Chiriva-Internati M (2012) Aging, cancer, and cancer vaccines. Immun Ageing 9:4. doi:10.​1186/​1742-4933-9-4 PubMed PubMedCentral CrossRef
  8.Chen IH, Lai YL, Wu CL, Chang YF, Chu CC, Tsai IF, Sun FJ, Lu YT (2010) Immune impairment in patients with terminal cancers: influence of cancer treatments and cytomegalovirus infection. Cancer Immunol Immunother 59:323–334. doi:10.​1007/​s00262-009-0753-0 PubMed CrossRef
  9.Verdecia BG, Hernández DS, Lorenzo-Luaces P, Alvarez TDJB, Rupalé IL, Herrera ZM, Ramos TC, Dávila AL (2013) Immunosenescence and gender: a study in healthy Cubans. Immun Ageing 10(1):16. doi:10.​1186/​1742-4933-10-16 CrossRef
  10.Gonzalez G, Diaz-Miqueli A, Crombet T, Raez LE, Lage A (2013) Current algorithm for treatment of advanced NSCLC patients: How to include active immunotherapy? J Cancer Ther 4(8A):59–75. doi:10.​4236/​jct.​2013.​48A010 CrossRef
  11.Neninger Vinageras E, de la Torre A, Osorio Rodríguez M, Catalá Ferrer M, Bravo I, Mendoza del Pino M, Abreu Abreu D, Acosta Brooks S, Rives R, del Castillo Carrillo C, González Dueñas M, Viada C, García Verdecia B, Crombet Ramos T, González Marinello G, Lage Dávila A (2008) Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer. J Clin Oncol 26(9):1452–1458. doi:10.​1200/​JCO.​2007.​11.​5980 PubMed CrossRef
  12.Fulop T, Larbi A, Witkowski JM, Kotb R, Hirokawa K, Pawelec G (2013) Immunosenescence and cancer. Crit Rev Oncog 18:489–513PubMed CrossRef
  13.Libri V, Azevedo RI, Jackson SE, Di Mitri D, Lachmann R, Fuhrmann S, Vukmanovic-Stejic M, Yong K, Battistini L, Kern F, Soares MV, Akbar AN (2011) Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4 + CD45RA + CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology 132:326–339. doi:10.​1111/​j.​1365-2567.​2010.​03386.​x PubMed PubMedCentral CrossRef
  14.Appay V, Sauce D, Prelog M (2010) The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals. Aging 2:78–81PubMed PubMedCentral
  15.Appay V, van Lier RA, Sallusto F, Roederer M (2008) Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 73:975–983. doi:10.​1002/​cyto.​a.​20643 PubMed CrossRef
  16.Larbi A, Fulop T (2014) From “truly naive” to “exhausted senescent” T cells: when markers predict functionality. Cytom A 85:25–35. doi:10.​1002/​cyto.​a.​22351 CrossRef
  17.Garcia B, Neninger E, de la Torre A, Leonard I, Martinez R, Viada C, Gonzalez G, Mazorra Z, Lage A, Crombet T (2008) Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine. Clin Cancer Res 14:840–846. doi:10.​1158/​1078-0432.​CCR-07-1050 PubMed CrossRef
  18.Fulop T, Kotb R, Fortin CF, Pawelec G, de Angelis F, Larbi A (2010) Potential role of immunosenescence in cancer development. Ann NY Acad Sci 1197:158–165. doi:10.​1111/​j.​1749-6632.​2009.​05370.​x PubMed CrossRef
  19.Gravekamp C (2011) The impact of aging on cancer vaccination. Curr Opin Immunol 23:555–560. doi:10.​1016/​j.​coi.​2011.​05.​003 PubMed PubMedCentral CrossRef
  20.Pritz T, Weinberger B, Grubeck-Loebenstein B (2014) The aging bone marrow and its impact on immune responses in old age. Immunol Lett 162(1 Pt B):310–315. doi:10.​1016/​j.​imlet.​2014.​06.​016 PubMed CrossRef
  21.Fulop T, Montgomery RR (2014) Editorial overview: immune senescence: known knowns and unknown unknowns. Curr Opin Immunol 29:7–9. doi:10.​1016/​j.​coi.​2014.​06.​005 CrossRef
  22.Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG (2000) Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 121:187–201PubMed CrossRef
  23.Strindhall J, Skog M, Ernerudh J, Bengner M, Lofgren S, Matussek A, Nilsson BO, Wikby A (2013) The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study. Age 35:985–991. doi:10.​1007/​s11357-012-9400-3 PubMed PubMedCentral CrossRef
  24.Whiteside TL (2013) Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes). Biochem Soc Trans 41:245–251. doi:10.​1042/​BST20120265 PubMed PubMedCentral CrossRef
  25.Akbar AN, Henson SM (2011) Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? Nat Rev Immunol 11:289–295. doi:10.​1038/​nri2959 PubMed CrossRef
  26.Derhovanessian E, Maier AB, Hahnel K, Beck R, de Craen AJ, Slagboom EP, Westendorp RG, Pawelec G (2011) Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. J Gen Virol 92:2746–2756. doi:10.​1099/​vir.​0.​036004-0 PubMed CrossRef
  27.McElhaney JE, Effros RB (2009) Immunosenescence: what does it mean to health outcomes in older adults? Curr Opin Immunol 21:418–424. doi:10.​1016/​j.​coi.​2009.​05.​023 PubMed PubMedCentral CrossRef
  28.Pallis AG, Hatse S, Brouwers B, Pawelec G, Falandry C, Wedding U, Lago LD, Repetto L, Ring A, Wildiers H (2014) Evaluating the physiological reserves of older patients with cancer: the value of potential biomarkers of aging? J Geriatr Oncol 5:204–218. doi:10.​1016/​j.​jgo.​2013.​09.​001 PubMed CrossRef
  29.Chang S, Kohrt H, Maecker HT (2014) Monitoring the immune competence of cancer patients to predict outcome. Cancer Immunol Immunother 63:713–719. doi:10.​1007/​s00262-014-1521-3 PubMed PubMedCentral CrossRef
  30.Gustafson MP, Lin Y, LaPlant B, Liwski CJ, Maas ML, League SC, Bauer PR, Abraham RS, Tollefson MK, Kwon ED, Gastineau DA, Dietz AB (2013) Immune monitoring using the predictive power of immune profiles. J Immunother Cancer 1:7. doi:10.​1186/​2051-1426-1-7 PubMed PubMedCentral CrossRef
  31.Kelloff GJ, Sigman CC (2012) Cancer biomarkers: selecting the right drug for the right patient. Nat Rev Drug Discov 11:201–214. doi:10.​1038/​nrd3651 PubMed CrossRef
  32.Lima L, Oliveira D, Ferreira JA, Tavares A, Cruz R, Medeiros R, Santos L (2015) The role of functional polymorphisms in immune response genes as biomarkers of bacille Calmette-Guérin (BCG) immunotherapy outcome in bladder cancer: establishment of a predictive profile in a Southern Europe population. BJU Int 116(5):753–63. doi:10.​1111/​bju.​12844 PubMed CrossRef
  
• 作者单位：Danay Saavedra (1)
  Beatriz García (1)
  Patricia Lorenzo-Luaces (1)
  Amnely González (1)
  Xitlally Popa (1)
  Karla P. Fuentes (1)
  Zaima Mazorra (1)
  Tania Crombet (1)
  Elia Neninger (2)
  Agustin Lage (1)
  
  1. Clinical Immunology Department, Center of Molecular Immunology, 216 St, Corner 15, PO Box 16040, Havana, Cuba
  2. Hermanos Ameijeiras Hospital, Havana, Cuba
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Cancer Research
  Immunology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0851

文摘

Purpose There are well-known alterations occurring within the immune system with aging. Collectively, these changes are known as immunosenescence. The incidence of malignancies also increases with age. The aim of this study was to determine the presence of immunosenescence biomarkers in non-small cell lung cancer (NSCLC) patients and to evaluate some of them as predictive biomarkers of CIMAvax-EGF cancer vaccine efficacy.