Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence
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- 作者：Agnieszka Przemska-Kosicka ; Caroline E. Childs ; Sumia Enani…
- 关键词：Ageing ; Influenza ; Prebiotic ; Probiotic ; Vaccination
- 刊名：Immunity & Ageing
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：13
- 期：1
- 全文大小：992 KB
- 刊物主题：Immunology; Geriatrics/Gerontology; Aging;
- 出版者：BioMed Central
- ISSN：1742-4933
文摘
Background Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and probiotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via alteration of the gut microbiota. This study investigated the effect of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52,486, combined with a prebiotic, gluco-oligosaccharide (B. longum + Gl-OS), on the response to seasonal influenza vaccination in young and older subjects in a double-blind, randomized controlled trial, taking into account the influence of immunosenescence markers at baseline.