Exposure assessment and heart rate variability monitoring in workers handling titanium dioxide particles: a pilot study
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- 作者：Sahoko Ichihara ; Weihua Li ; Seiichi Omura…
- 关键词：Titanium dioxide ; Heart rate variability ; Nanoparticles ; Nanomaterial exposure ; Health and environmental effects
- 刊名：Journal of Nanoparticle Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：18
- 期：3
- 全文大小：2,153 KB
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Weihua Li (2)
Seiichi Omura (3)
Yuji Fujitani (4)
Ying Liu (2)
Qiangyi Wang (2)
Yusuke Hiraku (5)
Naomi Hisanaga (6)
Kenji Wakai (7)
Xuncheng Ding (2)
Takahiro Kobayashi (3) (4) (9)
Gaku Ichihara (8)
1. Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan
2. Shanghai Institute of Planned Parenthood Research, WHO Collaborating Centre for Research in Human Reproduction, Shanghai, China
3. Tokyo Institute of Technology, Yokohama, Japan
4. National Institute for Environmental Studies, Tsukuba, Japan
5. Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan
6. Faculty of Human Science and Design, Aichi Gakusen University, Okazaki, Japan
7. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
9. Association for International Research Initiatives for Environmental Studies, 1-4-4 Ueno, Taito-ku, Tokyo, 110-0005, Japan
8. Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Japan - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Nanotechnology
Inorganic Chemistry
Characterization and Evaluation Materials
Physical Chemistry
Applied Optics, Optoelectronics and Optical Devices - 出版者：Springer Netherlands
- ISSN：1572-896X
文摘
Titanium dioxide (TiO2) particles are used for surface coating and in a variety of products such as inks, fibers, food, and cosmetics. The present study investigated possible respiratory and cardiovascular effects of TiO2 particles in workers exposed to this particle at high concentration in a factory in China. The diameter of particles collected on filters was measured by scanning electron microscopy. Real-time size-dependent particle number concentration was monitored in the nostrils of four workers using condensation particle counter and optical particle counter. Electrocardiogram was recorded using Holter monitors for the same four workers to record heart rate variability. Sixteen workers underwent assessment of the respiratory and cardiovascular systems. Mass-based individual exposure levels were also measured with personal cascade impactors. The primary particle diameter ranged from 46 to 562 nm. Analysis of covariance of the pooled data of the four workers showed that number of particles with a diameter <300 nm was associated positively with total number of N–N and negatively with total number of increase or decrease in successive RR intervals greater than 50 ms (RR50+/−) or percentage of RR 50+/− that were parameters of parasympathetic function. The total mass concentration was 9.58–30.8 mg/m3 during work, but significantly less before work (0.36 mg/m3). The clear abnormality in respiratory function was not observed in sixteen workers who had worked for 10 months to 13 years in the factory. The study showed that exposure to particles with a diameter <300 nm might affect HRV in workers handling TiO2 particles. The results highlight the need to investigate the possible impact of exposure to nano-scaled particles on the autonomic nervous system.