Depressive symptoms in first episode psychosis: a one-year follow-up study

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• 作者：Nasrettin S?nmez (1) (2)
  Kristin Lie Romm (1)
  Ole A Andreasssen (2)
  Ingrid Melle (2)
  Jan Ivar R?ssberg (1) (2)
  
• 刊名：BMC Psychiatry
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：204KB
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  43. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/13/106/prepub
  
• 作者单位：Nasrettin S?nmez (1) (2)
  Kristin Lie Romm (1)
  Ole A Andreasssen (2)
  Ingrid Melle (2)
  Jan Ivar R?ssberg (1) (2)
  
  1. (TIPS Sor Ost) Centre of Competence for Early Intervention in Psychosis, Oslo University Hospital, Fridtjof Nansens vei 12, Oslo, 0369, Norway
  2. KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction and Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Pb 85, Oslo, 0319, Norway
  

文摘

Background Depressive symptoms are common in patients with first episode psychosis (FEP) and have serious consequences for them. The main aims of this study were to examine the course of depression in FEP patients and explore whether any patient characteristics at baseline predicts depressive symptoms after one year. Method A total of 198 FEP patients with schizophrenia spectrum disorders were assessed for depressive symptoms with Calgary Depression Scale for Schizophrenia (CDSS) at baseline and 127 were followed for one year. A CDSS score [greater than or equal to] 6 was used as a cut-off score for depression. Results Approximately 50% of the patients were depressed (CDSS[greater than or equal to]6) at baseline. At follow-up approximately 35% had depression. The course of depressive symptoms varied, 26% was depressed at both baseline and follow-up, 9% became depressed during the follow-up, 22% remitted from depression during the 12 months and 43% was neither depressed at baseline nor at follow-up. Poor childhood social functioning, long duration of untreated psychosis (DUP) and depressive symptoms at baseline predicted depression at 12 months follow-up. Conclusion Depressive symptoms are frequent in the first year after onset of psychosis. Patients with poor social functioning in childhood, long DUP and depressive symptoms at baseline are more prone to have depressive symptoms after one year. These patients should be identified and proper treatment provided.