Imatinib relaxes the pulmonary venous bed of guinea pigs
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- 作者：Nina A. Maihöfer ; Said Suleiman ; Daniela Dreymüller ; Paul W. Manley…
- 关键词：Pulmonary veins ; Postcapillary resistance ; Pulmonary hypertension due to left heart disease ; Imatinib ; Tyrosine kinase inhibitors ; PDGFR
- 刊名：Respiratory Research
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：1306KB
- 刊物主题：Pneumology/Respiratory System;
- 出版者：BioMed Central
- ISSN：1465-993X
- 卷排序：18
文摘
BackgroundRecently, the IMPRES study revealed that systemic imatinib improves exercise capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the tyrosine kinase activity of the platelet-derived growth factor (PDGF)-receptor (PDGFR), acts antiproliferative and relaxes pulmonary arteries. However so far, the relaxant effects of imatinib on pulmonary veins (PVs) and on the postcapillary resistance are unknown, although pulmonary hypertension (PH) due to left heart disease (LHD) is most common and primarily affects PVs. Next, it is unknown whether activation of PDGFR alters the pulmonary venous tone. Due to the reported adverse effects of systemic imatinib, we evaluated the effects of nebulized imatinib on the postcapillary resistance.