Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging

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• 作者：Goran Papenberg (1) (2)
  Alireza Salami (1) (3)
  Jonas Persson (1)
  Ulman Lindenberger (2) (4)
  Lars B盲ckman (1)
  
  1. Aging Research Center ; Karolinska Institutet and Stockholm University ; G盲vlegatan 16 ; 113 30 ; Stockholm ; Sweden
  2. Center for Lifespan Psychology ; Max Planck Institute for Human Development ; Berlin ; Germany
  3. Integrative Medical Biology (Physiology) and Ume氓 Center for Functional Brain Imaging ; Ume氓 University ; Ume氓 ; Sweden
  4. Max Planck University College London Centre of Computational Psychiatry and Ageing Research ; London ; UK
  
• 关键词：Aging ; Functional brain imaging ; Cognition ; Genetics ; APOE ; BDNF ; COMT ; KIBRA
• 刊名：Neuropsychology Review
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：25
• 期：1
• 页码：47-62
• 全文大小：2,447 KB
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• 刊物类别：Behavioral Science
• 刊物主题：Psychology
  Neuropsychology
  Neurology
  Neuroradiology
  Health Psychology
  
• 出版者：Springer Netherlands
• ISSN：1573-6660

文摘

Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from age-comparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.