Phenolic Acids of the Two Major Blueberry Species in the US Market and Their Antioxidant and Anti-inflammatory Activities

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• 作者：Jie Kang (1) (4)
  Keshari M. Thakali (1)
  Gitte S. Jensen (2)
  Xianli Wu (3)
  
  1. USDA Arkansas Children鈥檚 Nutrition Center ; Department of Physiology and Biophysics ; University of Arkansas for Medical Sciences ; 15 Children鈥檚 Way ; Little Rock ; AR ; 72202 ; USA
  4. State Key Laboratory of Bioactive Substance and Function of Natural Medicines ; Institute of Materia Medica ; Chinese Academy of Medical Sciences & Peking Union Medical College ; Beijing ; 100050 ; People Republic of China
  2. NIS Labs ; 1437 Esplanade ; Klamath Falls ; OR ; 97601 ; USA
  3. Food Research and Technology ; The Hershey Company ; 1025 Reese Avenue ; Hershey ; PA ; 17033 ; USA
  
• 关键词：Anti ; inflammation ; Antioxidant ; Blueberries ; HPLC ; MS ; Phenolic acid
• 刊名：Plant Foods for Human Nutrition
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：70
• 期：1
• 页码：56-62
• 全文大小：472 KB
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• 刊物主题：Food Science; Chemistry/Food Science, general; Nutrition; Ecology; Plant Physiology;
• 出版者：Springer US
• ISSN：1573-9104

文摘

Highbush (cultivated) and lowbush (wild) are the two major blueberry species in the US market. Eight phenolic acids were detected and quantified from these two species by HPLC-MS. Chlorogenic acid was found to be the predominant phenolic acid in both species, with 0.44聽mg/g fresh weight in lowbush blueberries and 0.13聽mg/g fresh weight in highbush blueberries. Total phenolic content in lowbush blueberries is over three times higher than that of highbush blueberries. The phenolic acid mixtures representing those in the two species were prepared by using authentic standards to assess their contribution to total antioxidant and anti-inflammatory activities of the whole berries. Neither lowbush nor highbush blueberry phenolic acid mixture contributed significantly to the total antioxidant capacity of their relevant whole berries measured by oxygen radical absorbance capacity (ORAC). Both phenolic acid mixtures were able to enter the cell and showed in cell antioxidant activities from the cell based antioxidant protection of erythrocytes (CAP-e) assay. Lowbush blueberry phenolic acid mixture was found to show anti-inflammatory activities by inhibiting the nuclear factor-魏B (NF-魏B) activation and the production of inflammatory cytokines (TNF-伪 and IL-6) at the high dose.