AMPA/NMDA cooperativity and integration during a single synaptic event

详细信息    查看全文

• 作者：Vito Di Maio ; Francesco Ventriglia…
• 关键词：AMPA ; NMDA ; Glutamatergic synapse ; Synaptic model ; Spine resistance ; AMPA/NMDA cooperativity ; LPT
• 刊名：Journal of Computational Neuroscience
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：41
• 期：2
• 页码：127-142
• 全文大小：2,500 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  Human Genetics
  Theory of Computation
  
• 出版者：Springer Netherlands
• ISSN：1573-6873
• 卷排序：41

文摘

Coexistence of AMPA and NMDA receptors in glutamatergic synapses leads to a cooperative effect that can be very complex. This effect is dependent on many parameters including the relative and absolute number of the two types of receptors and biophysical parameters that can vary among synapses of the same cell. Herein we simulate the AMPA/NMDA cooperativity by using different number of the two types of receptors and considering the effect of the spine resistance on the EPSC production. Our results show that the relative number of NMDA with respect to AMPA produces a different degree of cooperation which depends also on the spine resistance.