The dual roles of cytokines in Alzheimer's disease: update on interleukins, TNF-α, TGF-β and IFN-γ
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- 作者：Cong Zheng ; Xin-Wen Zhou ; Jian-Zhi Wang
- 关键词：Alzheimer’s disease ; Cytokines ; Interleukins ; TNF ; α ; TGF ; β ; IFN ; γ
- 刊名：Translational Neurodegeneration
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：5
- 期：1
- 全文大小：598 KB
- 刊物主题：Neurosciences; Neurology;
- 出版者：BioMed Central
- ISSN：2047-9158
文摘
Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders in the elderly. Although the mechanisms underlying AD neurodegeneration are not fully understood, it is well recognized that inflammation plays a crucial role in the initiation and/or deterioration of AD neurodegeneration. Increasing evidence suggests that different cytokines, including interleukins, TNF-α, TGF-β and IFN-γ, are actively participated in AD pathogenesis and may serve as diagnostic or therapeutic targets for AD neurodegeneration. Here, we review the progress in understanding the important role that these cytokines or neuroinflammation has played in AD etiology and pathogenesis.