ILSI Health and Environmental Sciences Institute (HESI), global leader in advancing translational science to create science-based solutions for a sustainable, healthier world

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• 作者：Ayako Takei
• 关键词：Tripartite ; NPO ; Toxicology ; Risk assessment
• 刊名：Genes and Environment
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：37
• 期：1
• 全文大小：424KB
• 参考文献：1.HESI Website. www.鈥媓esiglobal.鈥媜rg
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  11.Hughes MF. Biomarkers of exposure: a case study with inorganic arsenic. Environ Health Perspect. 2006;114:1790鈥?.PubMed Central PubMed
  12.Gautier JC, Riefle B, Walter J, Kurth P, Mylecraine L, Guilpin V, et al. Evaluation of novel biomarkers of nephrotoxicity in two strains of rat treated with cisplatin. Toxicol Pathol. 2010;38:943鈥?6.PubMed CrossRef
  13.Harpur E, Ennulat D, Hoffman D, Betton G, Gautier JC, Riefke B, et al. Biological qualification of biomarkers of chemical-induced renal toxicity in two strains of male rat. Toxicol Sci. 2011;122:235鈥?2.PubMed CrossRef
  14.Hanson LS, Bass AS, Gintant G, Mittelstadt S, Rampe D, Thomas K. ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation. J Pharmacol Toxicol Methods. 2006;54:116鈥?9.PubMed CrossRef
  15.Bass AS, Darpo B, Breidenbach A, Bruse K, Feldman HS, Games D, et al. International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induces torsades de pointes. Br J Pharmacol. 2008;154:1491鈥?01.PubMed Central PubMed CrossRef
  16.Bass AS, Darpo B, Valentin JP, Sager P, Thomas K. Moving towards better predictors of drug-induced torsades de pointes. Br J Pharmacol. 2008;154:1550鈥?.PubMed Central PubMed CrossRef
  17.Trepakova ES, Koerner J, Pettit SD, Valentin JP. A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays. J Pharmacol Toxicol Methods. 2009;60:45鈥?0.PubMed CrossRef
  18.Pierson JB, Berridge BR, Brooks MB, Dreher K, Koerner J, Schulze AE, et al. A public-private consortium advances cardiac safety evaluation: Achievement of the HESI Cardiac Safety Technical Committee. J Pharmacol Toxicol Methods. 2013;68:7鈥?2.PubMed CrossRef
  19.Propose a Project. http://鈥媤ww.鈥媓esiglobal.鈥媜rg/鈥媔4a/鈥媝ages/鈥媔ndex.鈥媍fm?鈥媝ageid=鈥?540
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  22.WHO Chemical Risk Assessment Network Training Database. https://鈥媤ww.鈥媟isktraindb.鈥媜rg/鈥?/span>
  23.Pettit SD. Policy: from silos to multilingual science. Sci Trans Med. 2014;6:223鈥?.CrossRef
  
• 作者单位：Ayako Takei (1)
  
  1. ICaRuS Japan Limited, 3-4-2-4201 Toyosu, Koto-ku, Tokyo, 135-0061, Japan
  
• 刊物类别：Human Genetics;
• 刊物主题：Human Genetics;
• 出版者：BioMed Central
• ISSN：1880-7062

文摘

The Health and Environmental Sciences Institute (HESI) is a non-profit scientific research organization based in Washington, D.C., U.S.A. HESI was established in 1989 as a global branch of the International Life Sciences Institute (ILSI) to provide an international forum to advance the understanding of scientific issues related to human health, toxicology, risk assessment and the environment. For the last 25 years, HESI has been the global leader to advance application of new science and technologies in the areas of human health, toxicology, risk assessment and environment. The core principle of 鈥渢ripartite approach鈥?and the multi-sector operational model have successfully supported HESI鈥檚 scientific programs to create science-based solutions for a sustainable and healthier world. HESI鈥檚 achievements include the dataset to guide the selection of appropriate supporting assays for carcinogenicity testing, a new testing framework for agricultural chemicals with enhanced efficacy, predictivity, and reduced animal usage, novel biomarkers of nephrotoxicity which provide data on the location of timing of drug effects in the kidney allowing for enhanced drug development, etc. Keywords Tripartite NPO Toxicology Risk assessment