A powerful score-based statistical test for group difference in weighted biological networks

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• 作者：Jiadong Ji ; Zhongshang Yuan ; Xiaoshuai Zhang ; Fuzhong Xue
• 关键词：Network medicine ; Systems epidemiology ; Score ; based statistical test ; Network comparison
• 刊名：BMC Bioinformatics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：1,286 KB
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• 作者单位：Jiadong Ji (1)
  Zhongshang Yuan (1)
  Xiaoshuai Zhang (1)
  Fuzhong Xue (1)
  
  1. Department of Biostatistics, School of Public Health, Shandong University, PO Box 100, Jinan, 250012, Shandong, China
  
• 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Combinatorial Libraries; Algorithms;
• 出版者：BioMed Central
• ISSN：1471-2105

文摘

Background Complex disease is largely determined by a number of biomolecules interwoven into networks, rather than a single biomolecule. A key but inadequately addressed issue is how to test possible differences of the networks between two groups. Group-level comparison of network properties may shed light on underlying disease mechanisms and benefit the design of drug targets for complex diseases. We therefore proposed a powerful score-based statistic to detect group difference in weighted networks, which simultaneously capture the vertex changes and edge changes.