Psychological stress exacerbates NSAID-induced small bowel injury by inducing changes in intestinal microbiota and permeability via glucocorticoid receptor signaling
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- 作者：Kenichi Yoshikawa ; Chie Kurihara ; Hirotaka Furuhashi…
- 关键词：NSAID enteropathy ; HPA axis ; Fecal microbiota transplantation ; Small intestinal permeability ; Water avoidance stress
- 刊名：Journal of Gastroenterology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：52
- 期：1
- 页码：61-71
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Gastroenterology; Hepatology; Abdominal Surgery; Colorectal Surgery; Surgical Oncology;
- 出版者：Springer Japan
- ISSN：1435-5922
- 卷排序：52
文摘
BackgroundNonsteroidal anti-inflammatory drugs (NSAIDs) are popular painkillers, but they have serious side effects, not only in the upper gastrointestinal tract but also in the small intestine. It is well known that psychological stress may exacerbate various gastrointestinal diseases. The aim of this study was to determine whether psychological stress exacerbates NSAID enteropathy and to determine the possible underlying mechanisms for this.