Intestinal stem cell transplantation
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- 作者：Tetsuya Nakamura ; Mamoru Watanabe
- 关键词：Intestinal stem cell ; Organoid technology ; Transplantation ; Regenerative medicine
- 刊名：Journal of Gastroenterology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：52
- 期：2
- 页码：151-157
- 全文大小：559KB
- 刊物类别：Medicine
- 刊物主题：Gastroenterology; Hepatology; Abdominal Surgery; Colorectal Surgery; Surgical Oncology;
- 出版者：Springer Japan
- ISSN：1435-5922
- 卷排序：52
文摘
Organoid technologies to expand intestinal epithelial cells are gaining increasing attention as a useful tool to investigate many aspects of intestinal epithelial biology and pathology. One important application of organoid systems would be to use intestinal epithelial cells expanded in culture for following transplantation experiments. In this article, we present a brief overview of the studies that have succeeded in generating new epithelial tissues in the surface of native intestines in mice by organoid transplantation. We also discuss possible applications of this experimental approach in basic research on the intestinal epithelium as well as in regenerative medicine for various types of intestinal diseases in humans.