Detection of Active Sacroiliitis with Ankylosing Spondylitis through Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging

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• 作者：Ying-hua Zhao ; Shao-lin Li ; Zai-yi Liu ; Xin Chen ; Xiang-cheng Zhao…
• 关键词：Ankylosing spondylitis ; Active sacroiliitis ; Magnetic resonance imaging ; Diffusion ; weighted imaging ; Intravoxel incoherent motion
• 刊名：European Radiology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：25
• 期：9
• 页码：2754-2763
• 全文大小：6,451 KB
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• 作者单位：Ying-hua Zhao (1) (2)
  Shao-lin Li (1)
  Zai-yi Liu (2)
  Xin Chen (2)
  Xiang-cheng Zhao (1)
  Shao-yong Hu (1)
  Zhen-hua Liu (1)
  Ying-jie Mei MS (3)
  Queenie Chan (4)
  Chang-hong Liang (2)
  
  1. Department of Radiology, Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, 183 Zhongshan Da Dao Xi, Guangdong Province, Guangzhou, 510630, China
  2. Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, No.106, Zhongshan 2 Rd, Guangzhou, 510080, People’s Republic of China
  3. Philips Healthcare, Guangzhou 18F, Tower B, CIC No.33 Zhongshan san Road, YueXiu District, Guangzhou, 510055, China
  4. Philips Electronics Hong Kong Ltd, 6/F, Core Building 1, 1 Science Park East Avenue, Hong Kong Science Park, Shatin, New Territories, Hong Kong, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Diagnostic Radiology
  Interventional Radiology
  Neuroradiology
  Ultrasound
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1084

文摘

Objective To confirm feasibility and assess intravoxel incoherent motion (IVIM) to differentiate active sacroiliitis and ankylosing spondylitis.. Methods Forty-one patients were divided into two groups, an active group (n--0) and a chronic group (n--1), according to the Bath Ankylosing Spondylitis (AS) Disease Activity Index (BASDAI) and laboratory parameters. In addition, 21 healthy volunteers were chosen as the control group. Tissue diffusivity (Dslow), perfusion fraction (f), and pseudo-diffusion coefficient (Dfast) values were obtained for all three groups. One-way analysis of variance and receiver operating characteristic analysis were performed for all parameters. Results There was good interobserver agreement on the measurements between the two observers. The optimal cut-off values (with respective AUC, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio) between active and chronic groups were Dslow--.53?×-0??mm2/s (0.976, 90?%, 95.2?%, 18.9, 0.10) and f--.09 (0.545, 20?%, 95.5?%, 4.2, 0.84), and between chronic and control groups were Dslow = 0.22 × 10??mm2/s (0.517, 9.52?%, 100?%, no number, 0.9) and f = 0.09 (0.935, 95.24?%, 80.95?%, 5, 0.059). Conclusion Dslow and f of IVIM diffusion-weighted (DW)-MRI in AS show a significant difference in the values of diffusion of water molecules and fractional perfusion-related volume among the three groups. Key Points -D slow can be used to differentiate the activity of AS. -With perfusion fraction, the sensitivity of differentiating the AS activity is improved. -IVIM DWI plays an important role in detecting the activity in patients with AS.