Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0?T in nasopharyngeal carcinoma

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• 作者：Qian-Jun Jia (1)
  Shui-Xing Zhang (1)
  Wen-Bo Chen (1)
  Long Liang (1)
  Zheng-Gen Zhou (1)
  Qian-Hui Qiu (2)
  Zai-Yi Liu (1)
  Qiong-Xin Zeng (1)
  Chang-Hong Liang (1)
  
• 关键词：Nasopharyngeal carcinoma ; Intravoxel incoherent motion (IVIM) ; Diffusion ; weighted MR imaging ; Dynamic contrast ; enhanced MR imaging ; Perfusion
• 刊名：European Radiology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：24
• 期：12
• 页码：3076-3087
• 全文大小：10,080 KB
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• 作者单位：Qian-Jun Jia (1)
  Shui-Xing Zhang (1)
  Wen-Bo Chen (1)
  Long Liang (1)
  Zheng-Gen Zhou (1)
  Qian-Hui Qiu (2)
  Zai-Yi Liu (1)
  Qiong-Xin Zeng (1)
  Chang-Hong Liang (1)
  
  1. Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, 106 Zhong Shan Er Road, Guangzhou, Guangdong Province, 510080, People’s Republic of China
  2. Department of Otolaryngology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, 106 Zhong Shan Er Road, Guangzhou, Guangdong Province, 510080, People’s Republic of China
  
• ISSN：1432-1084

文摘

Purpose To determine the correlation between intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters. Methods Thirty-eight newly diagnosed NPC patients were prospectively enrolled. Diffusion-weighted images (DWI) at 13 b-values were acquired using a 3.0-T MRI system. IVIM parameters including the pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f), DCE-MRI parameters including maximum slope of increase (MSI), enhancement amplitude (EA) and enhancement ratio (ER) were calculated by two investigators independently. Intra- and interobserver agreement were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Relationships between IVIM and DCE-MRI parameters were evaluated by calculation of Spearman’s correlation coefficient. Results Intra- and interobserver reproducibility were excellent to relatively good (ICC-em class="a-plus-plus">=-.887-0.997; narrow width of 95?% limits of agreement). The highest correlation was observed between f and EA (r--.633, P--.001), with a strong correlation between f and MSI (r--.598, P--.001). No correlation was observed between f and ER (r--0.162; P--.421) or D* and DCE parameters (r--.125-.307; P--.119). Conclusion This study suggests IVIM perfusion imaging using 3.0-T MRI is feasible in NPC, and f correlates significantly with EA and MSI. Key Points -Assessment of tumour perfusion is important in nasopharyngeal carcinoma. -DCE-MRI provided perfusion information with the use of intravenous contrast media. -Perfusion information could be provided by non-invasive IVIM MRI. -IVIM parameter f correlated with DCE-MRI parameters.