Selenium Deficiency Influences Nitric Oxide and Selenoproteins in Pancreas of Chickens

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• 作者：Xia Zhao (1)
  Haidong Yao (1)
  Ruifeng Fan (1)
  Ziwei Zhang (1)
  Shiwen Xu (1)
  
• 关键词：Selenium (Se) deficiency ; Selenoproteins ; Chickens ; Pancreas ; Nitric oxide (NO)
• 刊名：Biological Trace Element Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：161
• 期：3
• 页码：341-349
• 全文大小：683 KB
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• 作者单位：Xia Zhao (1)
  Haidong Yao (1)
  Ruifeng Fan (1)
  Ziwei Zhang (1)
  Shiwen Xu (1)
  
  1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China
  
• ISSN：1559-0720

文摘

Selenium (Se) deficiency induces pancreatic atrophy in chickens, but the molecular mechanism remains unclear. In this study, we investigated the effect of dietary Se deficiency on the expressions of 25 selenoproteins and the content of nitric oxide (NO) and examined the relationship between selenoproteins and NO. Chickens (180; 1?day old) were randomly divided into two groups, low (L) group (fed with Se deficient (Se 0.033?mg/kg) diet) and control (C) group (fed with normal (Se 0.2?mg/kg) diet). Then, pancreas was collected at 15, 25, 35, 45, and 55?days, and the content of NO, the activity of inducible NO synthase (iNOS), and the messenger RNA (mRNA) levels of 25 selenoproteins and iNOS were measured. The results showed that 25 selenoproteins were decreased (P--.05) by Se deficiency. Among them, thioredoxin reductase 1 (TXNRD1), selenoprotein S (SELS), selenoprotein U (SELU), selenoprotein X1 (SEPX1), and selenoprotein synthetase 2 (SPS2) were highly and extensively expressed than other types of selenoproteins in pancreas of chickens (P--.05). Thioredoxin reductase 2 (TXNRD2), glutathione peroxidase 1 (GPX1), glutathione peroxidase 3 (GPX3), selenoprotein I (SELI), iodothyronine deiodinase 1 (DIO1), selenoprotein P1 (SEPP1), selenoprotein W1 (SEPW1), selenoprotein O (SELO), selenoprotein T (SELT), selenoprotein M (SELM), selenoprotein X1 (SEPX1), and SPS2 were excessively decreased (P--.05). Meanwhile, NO content, iNOS activity, and mRNA level were increased strikingly compared with C group (P--.05). The correlation analysis suggested that NO had a strong negative correlation with GPX1, glutathione peroxidase 2 (GPX2), GPX3, DIO1, selenoprotein K (SELK), SELI, SEPX1, and SPS2. These results suggested that Se deficiency induced pancreatic injury by influencing NO and selenoproteins in pancreas of chickens. Thus, it offers some information on the mechanism of pancreatic injury induced by Se deficiency.