Descriptive statistics of disallowed regions and various protein secondary structures in the context of studying twisted β-hairpins
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- 作者：I. Yu. Torshin ; L. A. Uroshlev ; N. G. Esipova ; V. G. Tumanyan
- 刊名：Biophysics
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：61
- 期：1
- 页码：6-12
- 全文大小：450 KB
- 刊物主题：Biophysics and Biological Physics;
- 出版者：Springer US
- ISSN：1555-6654
- 卷排序：61
文摘
A detailed analysis of polypeptide-chain backbone conformations was carried out for polypeptide-chain segments adjacent to β-turn regions, including the sites of disallowed conformations. A cross comparison of conformations was performed for disallowed regions of the Ramachandran plot and main types of β-turns and adjacent secondary structures. Based on the results, disallowed region 2 (II, II') in the Ramachandran plot was shown to coincide mainly with β-hairpins and, more exactly, twisted β-hairpins. The frequency of residues with angles ϕi, ψi that fall in region 2 (II, II') in the latter is 140 times higher than in common β-hairpins.Keywordsdisallowed conformationsβ-hairpinβ-turnconformation analysisstatistical analysis