Early-life stress increases the motility of microglia in adulthood

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• 作者：Yusuke Takatsuru (1) (3)
  Junichi Nabekura (2) (4)
  Tatsuya Ishikawa (2) (3)
  Shin-ichi Kohsaka (5)
  Noriyuki Koibuchi (1)
  
  1. Department of Integrative Physiology ; Gunma University Graduate School of Medicine ; Maebashi ; Gunma ; 371-8511 ; Japan
  3. CREST ; Japan Science and Technology Agency ; Kawaguchi ; 332-0012 ; Japan
  2. Division of Homeostatic Development ; National Institute for Physiological Sciences ; Okazaki ; Aichi ; 444-8585 ; Japan
  4. The Graduate University for Advanced Studies ; Hayama ; Kanagawa ; 240-0193 ; Japan
  5. Department of Neurochemistry ; National Institute of Neuroscience ; Kodaira ; Tokyo ; 187-8502 ; Japan
  
• 关键词：Maternal deprivation ; In vivo imaging ; In vivo microdialysis ; Somatosensory cortex
• 刊名：The Journal of Physiological Sciences
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：65
• 期：2
• 页码：187-194
• 全文大小：400 KB
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• 刊物主题：Human Physiology; Neurosciences; Animal Biochemistry; Animal Physiology; Cell Physiology; Neurobiology;
• 出版者：Springer Japan
• ISSN：1880-6562

文摘

Early-life stress may cause several neuropsychological disorders in adulthood. Such disorders may be induced as a result of instability of neuronal circuits and/or synaptic formation. However, the mechanisms underlying such instability have not yet been clearly understood. We previously reported that the mushroom spine in the somatosensory cortex (SSC) is unstable in early-life stressed mice not only in the juvenile stage but also in adulthood. In this study, we measured the number and motility of microglial processes in early-life stressed mice to understand the mechanism further. We found that the number and motility of filopodia-like protrusions of microglial processes tended to increase in the SSC of early-life stressed mice. Interestingly, the motility of protrusions correlated significantly with the nociceptive threshold level measured by the von Frey test. These results indicated that the activity of microglia affected the neuronal function in early-life stressed mice.