Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors

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• 作者：Lucyna Kaszubowska ; Jerzy Foerster ; Jan Jacek Kaczor ; Daria Schetz…
• 关键词：NK cells ; Ageing ; Immunosenescence ; Seniors ; SIRT1 ; HSP70 ; SOD2 ; Oxidative stress ; Innate immunity
• 刊名：Immunity & Ageing
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：1164KB
• 刊物主题：Immunology; Geriatrics/Gerontology; Aging; Public Health; Clinical Nutrition; Antibodies;
• 出版者：BioMed Central
• ISSN：1742-4933
• 卷排序：14

文摘

BackgroundNK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression of proteins involved in cellular stress response sirtuin 1 (SIRT1), heat shock protein 70 (HSP70) and manganese superoxide dismutase (SOD2) in non-stimulated NK cells of the oldest seniors (n = 25; aged over 85; mean age 88 years) and compare with NK cells of the old (n = 30; aged under 85; mean age 76 years) and the young (n = 32; mean age 21 years) to find potential relationships between the level of expression of these proteins in NK cells and longevity. The concentration of carbonyl groups and 8-isoprostanes in NK cell lysates reflecting the level of oxidative stress was also measured.