Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum

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• 作者：Ji Young Lee ; Kwang-Jin Kim ; Jinhee Kim ; Sang Un Choi…
• 刊名：Archives of Pharmacal Research
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：39
• 期：5
• 页码：713-720
• 全文大小：1,100 KB
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786
• 卷排序：39

文摘

A phytochemical investigation for the rhizome extract from Sinomenium acutum (Menispermaceae) resulted in the isolation of several active principles responsible for the anti-osteoclastogenic property of the extract, together with related isoquinoline alkaloids (1–13) including two new compounds, 1 and 2. Among isolated compounds, salutaridine (7), dauricumine (10), cheilanthifoline (12), and dauriporphine (13) were observed to give significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts, respectively. The chemical structures of two newly isolated compounds, 1 and 2 were established as 8-demethoxycephatonine (1) and 7(R)-7,8-dihydrosinomenine (2), by spectroscopic analyses including 2D NMR experiments.KeywordsSinomenium acutumMenispermaceaeIsoquinoline alkaloidsAnti-osteoclastogenic effect