Background 99mTc-methoxyisobutylisonitrile uptake of breast-specific gamma imaging in relation to background parenchymal enhancement in magnetic resonance imaging
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- 作者：Hai-Jeon Yoon (1)
Yemi Kim (2)
Jee Eun Lee (3)
Bom Sahn Kim (1) - 关键词：Breast imaging ; Breast ; specific gamma imaging ; Magnetic resonance imaging ; Menopause ; Mammographic breast density
- 刊名：European Radiology
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：25
- 期：1
- 页码：32-40
- 全文大小：1,370 KB
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Yemi Kim (2)
Jee Eun Lee (3)
Bom Sahn Kim (1)
1. Department of Nuclear Medicine, Ewha Womans University, 911-1 Mok-Dong, Yangchun-Ku, Seoul, 158-710, Republic of Korea
2. Clinical Research Institute and Department of Conservative Dentistry, Ewha Womans University, Seoul, Republic of Korea
3. Department of Radiology, Ewha Womans University, Seoul, Republic of Korea - ISSN：1432-1084
文摘
Objectives This study investigated factors that could affect background uptake of 99mTc- methoxyisobutylisonitrile (MIBI) on normal breast by breast-specific gamma imaging (BSGI). In addition, the impact of background 99mTc-MIBI uptake on the diagnostic performance of BSGI was further investigated. Methods One hundred forty-five women with unilateral breast cancer who underwent BSGI, MRI, and mammography were retrospectively enrolled. Background uptake on BSGI was evaluated qualitatively and quantitatively. Patients were classified into non-dense and dense breast groups according to mammographic breast density. Background parenchymal enhancement (BPE) was rated according to BI-RADS classification. The relationship of age, menopausal status, mammographic breast density, and BPE with background 99mTc-MIBI uptake was analyzed. Results Heterogeneous texture and high background uptake ratio on BSGI were significantly correlated with younger age (p--.001, respectively), premenopausal status (p--.001 and p--.003), dense breast (p--.001, respectively), and marked BPE (p--.001, respectively). On multivariate analysis, only BPE remained a significant factor for background MIBI uptake (p--.001).There was a significant reduction in positive predictive value (p--.024 and p--.002) as background MIBI uptake and BPE grade increased. Conclusions BPE on MRI was the most important factor for background MIBI uptake on BSGI. High background MIBI uptake or marked BPE can diminish the diagnostic performance of BSGI. Key Points -Age, menopause, density, and background parenchymal enhancement affect background MIBI uptake. -BPE is an independent factor for background MIBI uptake on BSGI. -Marked BPE may impair BSGI interpretation.