Highly efficient synthesis of quinoxaline derivatives from 1,2-benzenediamine and \(\alpha \

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• 作者：Jianwei Yan ; Yanhong Xu ; Fangfang Zhuang ; Jie Tian ; Guisheng Zhang
• 关键词：\(\alpha \) ; Aminoxylated dicarbonyl compounds ; Quinoxaline ; Pyrazine ; Pyridopyrazine ; Benzoxazin ; 2 ; one
• 刊名：Molecular Diversity
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：20
• 期：2
• 页码：567-573
• 全文大小：741 KB
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• 作者单位：Jianwei Yan (1) (2)
  Yanhong Xu (2)
  Fangfang Zhuang (2)
  Jie Tian (2)
  Guisheng Zhang (1)
  
  1. Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, Henan, People’s Republic of China
  2. School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, People’s Republic of China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Polymer Sciences
  Organic Chemistry
  Pharmacy
  
• 出版者：Springer Netherlands
• ISSN：1573-501X

文摘

Simple and efficient synthetic procedures for the preparation of quinoxaline, pyrazine, pyridopyrazine, and benzoxazin-2-one derivatives were developed. The one-pot cascade process involves the acidic elimination of \(\alpha \)-aminoxylated dicarbonyl compounds to generate 1,2,3-tricarbonyl compounds and subsequent condensation with 1,4-N,N or -N,O dinucleophiles to afford quinoxaline, pyrazine, pyridopyrazine, and benzoxazin-2-one scaffolds. All the proposed processes do not need extra catalysts, dry solvents, or harsh reaction conditions.