Endometrial preparation protocol of the frozen-thawed embryo transfer in patients with polycystic ovary syndrome
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- 作者：Jianmei Yu ; Yanping Ma ; Ze Wu ; Yonggang Li…
- 关键词：Frozen ; thawed embryo transfer ; Endometrial preparation ; Artificial cycle ; Induced ovulation ; Pregnancy rate
- 刊名：Archives of Gynecology and Obstetrics
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：291
- 期：1
- 页码：201-211
- 全文大小：321 KB
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Gynecology
Obstetrics and Perinatology
Endocrinology
Human Genetics - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0711
文摘
Purpose To assess which is the optimal protocol in terms of endometrial preparation prior to frozen-thawed embryo transfer (FET) in women with polycystic ovarian syndrome (PCOS) and to explore the effect in stimulated cycle with the addition of vaginal 17-β oestradiol. Methods Five hundred and seventy-six patients with PCOS were prepared for FET using artificial cycle induced with oestradiol and progesterone supplementation (n?=?291) and stimulated cycle induced by human menopausal gonadotrophin (HMG) within or without the addition of vaginal 17-β oestradiol (n?=?285). Then the FET was performed in a receptive endometrium. Results Endometrial thickness was similar (9.03?±?1.65 vs. 9.12?±?1.58, P?>?0.05) in artificial and stimulated cycle. The two protocols resulted in clinical pregnancy rate (41.0- vs. 41.6?%, P?>?0.05), ongoing pregnancy rate (36.6- vs. 34.7?%, P?>?0.05), live birth rate (30.0- vs. 31.7?%, P?>?0.05), which were not statistically different. Nevertheless, the cancelled cycle rate made a significant difference (2.2- vs. 5.4?%, P? Conclusions The mean endometrial thickness, clinical pregnancy rate, ongoing pregnancy rate, live birth rate and implantation rate were similar in artificial and stimulated cycle for endometrial preparation prior to FET in PCOS. It was fine to add vaginal 17-β oestradiol to stimulated cycle when necessary. However, stimulated cycles had a significantly higher cancelled cycle rate. We should follow the principles of individualization, securitization and optimization in endometrial preparation of the FET in patients with PCOS.