Toll-like receptor 3 inhibits Newcastle disease virus replication through activation of pro-inflammatory cytokines and the type-1 interferon pathway
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- 作者：Jinghua Cheng (1) (2)
Yingjie Sun (2)
Xiaorong Zhang (1)
Fanqing Zhang (3)
Shilei Zhang (2)
Shengqing Yu (2)
Xusheng Qiu (2)
Lei Tan (2)
Cuiping Song (2)
Song Gao (1)
Yantao Wu (1)
Chan Ding (2) - 刊名：Archives of Virology
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：159
- 期：11
- 页码：2937-2948
- 全文大小：3,349 KB
- 参考文献：1. Alexander D (1997) Newcastle disease and other avian Paramyxoviridae infections. In: Caineck BW (ed) Diseases of poultry. Iowa State University Press, Ames, pp 541-69
2. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732-38 CrossRef
3. Boukhvalova MS, Sotomayor TB, Point RC, Pletneva LM, Prince GA, Blanco JC (2010) Activation of interferon response through toll-like receptor 3 impacts viral pathogenesis and pulmonary toll-like receptor expression during respiratory syncytial virus and influenza infections in the cotton rat / Sigmodon hispidus model. J Interferon Cytokine Res: Off J Int Soc Interferon Cytokine Res 30:229-42 CrossRef
4. Doyle SE, O’Connell R, Vaidya SA, Chow EK, Yee K, Cheng G (2003) Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor. J Immunol (Baltimore, Md: 1950) 170:3565-571 CrossRef
5. Fournier P, Wilden H, Schirrmacher V (2012) Importance of retinoic acid-inducible gene I and of receptor for type I interferon for cellular resistance to infection by Newcastle disease virus. Int J Oncol 40:287-98
6. Garcia-Sastre A, Biron CA (2006) Type 1 interferons and the virus-host relationship: a lesson in detente. Science (New York, NY) 312:879-82 CrossRef
7. Goodbourn S, Didcock L, Randall RE (2000) Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J Gen Virol 81:2341-364
8. Hewson CA, Jardine A, Edwards MR, Laza-Stanca V, Johnston SL (2005) Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells. J Virol 79:12273-2279 CrossRef
9. Isogawa M, Robek MD, Furuichi Y, Chisari FV (2005) Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol 79:7269-272 CrossRef
10. Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987-95 CrossRef
11. Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X (2003) Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem 278:16713-6719 CrossRef
12. Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S (2005) Cell type-specific involvement of RIG-I in antiviral response. Immunity 23:19-8 CrossRef
13. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-05
14. Lamb RA, Griffin DE (2007) Paramyxoviridae: the viruses and their replication. In: Knipe DM (ed) Field virology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1449-496
15. Lau YF, Tang LH, Ooi EE, Subbarao K (2010) Activation of the innate immune system provides broad-spectrum protection against influenza A viruses with pandemic potential in mice. Virology 406:80-7 CrossRef
16. Le Goffic R, Pothlichet J, Vitour D, Fujita T, Meurs E, Chignard M, Si-Tahar M (2007) Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J Immunol 178:3368-372
17. Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2:725-34 Jinghua Cheng (1) (2)
Yingjie Sun (2)
Xiaorong Zhang (1)
Fanqing Zhang (3)
Shilei Zhang (2)
Shengqing Yu (2)
Xusheng Qiu (2)
Lei Tan (2)
Cuiping Song (2)
Song Gao (1)
Yantao Wu (1)
Chan Ding (2)
1. Jiangsu Co-Innovation Center for Prevention and Control of Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, Yangzhou, 225009, Jiangsu, People’s Republic of China
2. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 518 Ziyue Road, Shanghai, 200241, People’s Republic of China
3. College of Veterinary Medicine, Nanjing Agriculture University, Nanjing, 210095, Jiangsu, People’s Republic of China - ISSN：1432-8798
文摘
Newcastle disease virus (NDV) is an avian paramyxovirus that can selectively replicate in and destroy human tumor cells. In this report, we demonstrate that NDV infection in HeLa cells leads to the activation of the pattern recognition Toll-like receptor 3 (TLR3). Overexpression of TLR3 enhanced the activity of the IFN-β promoter and the transcription factor NF-kappa B (NF-κB), thereby decreasing viral protein synthesis and the virus titer. In addition, the reduction of endogenous TLR3 by small interfering RNA (siRNA) increased NDV replication. Similar anti-NDV effects were observed in DF-1 chicken fibroblast cells with the exogenous expression of chicken TLR3 (cTLR3). Immunofluorescence staining of HeLa cells indicated that the dsRNA generated during NDV replication colocalized with TLR3 in punctate subcellular structures. Altogether, our results strongly suggest that TLR3 actively participates in the recognition of the innate pro-inflammatory response after NDV infection and leads to the consequent antiviral cytokine/interferon secretion.
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