A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40
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- 作者：Jingtao Chen ; Gerard Zurawski ; Sandy Zurawski…
- 关键词：Mantle cell lymphoma ; Cyclin D1 ; Vaccine ; Dendritic cells ; Tumor antigen
- 刊名：Journal of Hematology & Oncology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：8
- 期：1
- 全文大小：2,132 KB
- 刊物主题：Oncology; Hematology; Cancer Research;
- 出版者：BioMed Central
- ISSN：1756-8722
文摘
Background Mantle cell lymphoma (MCL) is a distinct clinical pathologic subtype of B cell non-Hodgkin’s lymphoma often associated with poor prognosis. New therapeutic approaches based on boosting anti-tumor immunity are needed. MCL is associated with overexpression of cyclin D1 thus rendering this molecule an interesting target for immunotherapy.