Effect of amitriptyline on tetrodotoxin-resistant Nav1.9 currents in nociceptive trigeminal neurons

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• 作者：Jingyao Liang (3)
  Xiaoyan Liu (4)
  Jianquan Zheng (4)
  Shengyuan Yu (3)
  
• 关键词：Amitriptyline ; Nav1.9 ; Patch clamp ; Trigeminal ganglion ; Pain
• 刊名：Molecular Pain
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：9
• 期：1
• 全文大小：459KB
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• 作者单位：Jingyao Liang (3)
  Xiaoyan Liu (4)
  Jianquan Zheng (4)
  Shengyuan Yu (3)
  
  3. Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, PR China
  4. Department of Biochemical Pharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China
  

文摘

Background Amitriptyline (AMI) is tricyclic antidepressant that has been widely used to manage various chronic pains such as migraines. Its efficacy is attributed to its blockade of voltage-gated sodium channels (VGSCs). However, the effects of AMI on the tetrodotoxin-resistant (TTX-r) sodium channel Nav1.9 currents have been unclear to present. Results Using a whole-cell patch clamp technique, this study showed that AMI efficiently inhibited Nav1.9 currents in a concentration-dependent manner and had an IC50 of 15.16?μM in acute isolated trigeminal ganglion (TG) neurons of the rats. 10?μM AMI significantly shifted the steady-state inactivation of Nav1.9 channels in the hyperpolarizing direction without affecting voltage-dependent activation. Surprisingly, neither 10 nor 50?μM AMI caused a use-dependent blockade of Nav1.9 currents elicited by 60 pulses at 1?Hz. Conclusion These data suggest that AMI is a state-selective blocker of Nav1.9 channels in rat nociceptive trigeminal neurons, which likely contributes to the efficacy of AMI in treating various pains, including migraines.