CD20-negative diffuse large B cell lymphoma: a comprehensive analysis of 695 cases
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- 作者：Jing Li ; Shu Zhao ; Jingxuan Wang ; Jingyu Chen ; Wen Wen ; Qingyuan Zhang
- 刊名：Tumor Biology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：37
- 期：3
- 页码：3619-3637
- 全文大小：554 KB
- 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
- 卷排序：37
文摘
CD20 expression is absent in a variety of diffuse large B cell lymphomas (DLBCLs), including plasmablastic lymphoma, primary effusion lymphoma, anaplastic lymphoma, kinase-positive DLBCL, and large B cell lymphoma arising in human herpesvirus 8-associated multicentric Castleman disease. These rare and heterogeneous tumors are characterized by the presence of proliferating immunoblasts with similar transcriptional profiles as those of plasma cells and are typically associated with highly aggressive pathologies, with high levels of chemotherapy resistance and low survival rates; thus, they pose significant diagnostic and treatment challenges. We conducted a systematic literature review of the limited existing clinical data to summarize the current knowledge regarding the biological basis, diagnostic limits, and potential therapeutic targets of distinct variants of CD20-negative DLBCL. This review will hopefully increase the awareness of these rare disorders among clinicians and pathologists and prompt basic and clinical research.KeywordsCD20-negativePlasmablastic lymphomaPrimary effusion lymphomaALK-positive DLBCLMulticentric Castleman disease