Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice

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• 作者：Jung-Cheol Park ; Jinhua Ma ; Won Kyung Jeon…
• 关键词：Fructus mume ; Alzheimer’s disease ; Cognition ; Choline acetyltransferase ; 5XFAD
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：1
• 全文大小：572 KB
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• 作者单位：Jung-Cheol Park (1)
  Jinhua Ma (1)
  Won Kyung Jeon (2)
  Jung-Soo Han (1)
  
  1. Department of Biological Sciences, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701, Republic of Korea
  2. Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 305-811, Republic of Korea
  
• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882

文摘

Background Fructus mume (F. mume) has been used as a traditional treatment for ulcer, cough, and digestive problems for many years in Asian countries. Previous studies have demonstrated that F. mume extracts alleviate cognitive deficits in rats with chronic cerebral hypoperfusion and in mice with scopolamine treatments. The present experiment was conducted to examine the effects of F. mume on cognitive impairments in 5XFAD transgenic mice with five familial Alzheimer’s disease (AD) mutations.