Determination of volatile residual solvents in pharmaceutical products by headspace liquid-phase microextraction gas chromatography-flame ionization detector

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• 作者：Xia Wang ; Ting Jiang ; Jinpeng Yuan ; Chuange Cheng ; Jianhua Liu ; Junbo Shi and Rusong Zhao
• 关键词：Volatile residual solvents ; HS ; LPME ; Flame ionization detector ; Pharmaceutical products
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2006
• 出版时间：July 2006
• 年：2006
• 卷：385
• 期：6
• 页码：1082-1086
• 全文大小：113 KB

文摘

This paper demonstrates headspace liquid-phase microextraction (HS-LPME) as used for the determination of volatile residual solvents in pharmaceutical products. This method is based on headspace liquid-phase microextraction capillary column gas chromatography. Under optimum conditions, the linerary of the method ranged from 1 to 1,000 mg l−1. The limits of detection are 0.2–2.0 mg l−1 and relative standard deviations (RSD) for most of the volatile solvents were below 10 % . This novel method is applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results.