Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice

详细信息    查看全文

• 作者：Jinxiu Rui ; Songyan Deng ; Jasmin Lebastchi ; Pamela L. Clark…
• 关键词：Beta cell ; Cytokines ; DNA methylation ; DNA methyltransferases ; Dnmt3a ; Infiltrating lymphocytes ; Ins1 ; Ins2 ; Type 1 diabetes
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：59
• 期：5
• 页码：1021-1029
• 全文大小：637 KB
• 参考文献：1.Herold KC, Vignali DA, Cooke A, Bluestone JA (2013) Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 13:243–256CrossRef PubMed PubMedCentral
  2.Atkinson MA, Eisenbarth GS, Michels AW (2014) Type 1 diabetes. Lancet 383:69–82CrossRef PubMed PubMedCentral
  3.Mathis D, Vence L, Benoist C (2001) Beta-cell death during progression to diabetes. Nature 414:792–798CrossRef PubMed
  4.Sherry NA, Chen W, Kushner JA et al (2007) Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology 148:5136–5144CrossRef PubMed
  5.Kuroda A, Rauch TA, Todorov I et al (2009) Insulin gene expression is regulated by DNA methylation. PLoS One 4:e6953CrossRef PubMed PubMedCentral
  6.Dhawan S, Tschen SI, Zeng C et al (2015) DNA methylation directs functional maturation of pancreatic beta cells. J Clin Invest 125:2851–2860CrossRef PubMed PubMedCentral
  7.Kowluru RA, Santos JM, Mishra M (2013) Epigenetic modifications and diabetic retinopathy. Biomed Res Int 2013:635284CrossRef PubMed PubMedCentral
  8.Takizawa F, Mizutani S, Ogawa Y, Sawada N (2013) Glucose-independent persistence of PAI-1 gene expression and H3K4 tri-methylation in type 1 diabetic mouse endothelium: implication in metabolic memory. Biochem Biophys Res Commun 433:66–72CrossRef PubMed
  9.Ishikawa K, Tsunekawa S, Ikeniwa M et al (2015) Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. PLoS One 10:e0115350CrossRef PubMed PubMedCentral
  10.Alonso LC, Yokoe T, Zhang P et al (2007) Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes 56:1792–1801CrossRef PubMed PubMedCentral
  11.El-Osta A, Brasacchio D, Yao D et al (2008) Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med 205:2409–2417CrossRef PubMed PubMedCentral
  12.Mitic T, Emanueli C (2012) Diabetes-induced epigenetic signature in vascular cells. Endocr Metab Immune Disord Drug Targets 12:107–117CrossRef PubMed
  13.Feng B, Ruiz MA, Chakrabarti S (2013) Oxidative-stress-induced epigenetic changes in chronic diabetic complications. Can J Physiol Pharmacol 91:213–220CrossRef PubMed
  14.Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33(Suppl):245–254CrossRef PubMed
  15.Alvarado S, Fernald RD, Storey KB, Szyf M (2014) The dynamic nature of DNA methylation: a role in response to social and seasonal variation. Integr Comp Biol 54:68–76CrossRef PubMed PubMedCentral
  16.Zardo G, Fazi F, Travaglini L, Nervi C (2005) Dynamic and reversibility of heterochromatic gene silencing in human disease. Cell Res 15:679–690CrossRef PubMed
  17.Diana J, Simoni Y, Furio L et al (2013) Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat Med 19:65–73CrossRef PubMed
  18.Jayaraman S (2011) Assessment of beta cell viability. Curr Protoc Cytom 55.6.27:6.27.1–6.27.16
  19.Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC (2006) Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 55:3238–3245CrossRef PubMed
  20.Wachlin G, Augstein P, Schroder D et al (2003) IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction. J Autoimmun 20:303–312CrossRef PubMed
  21.Lehuen A, Diana J, Zaccone P, Cooke A (2010) Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol 10:501–513CrossRef PubMed
  22.Lakey JR, Suarez-Pinzon WL, Strynadka K et al (2001) Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells. Lab Invest 81:1683–1692CrossRef PubMed
  23.Weir GC, Bonner-Weir S (2004) Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 53(Suppl 3):S16–S21CrossRef PubMed
  24.Weir GC, Bonner-Weir S (2013) Islet beta cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci 1281:92–105CrossRef PubMed PubMedCentral
  25.Akirav EM, Lebastchi J, Galvan EM et al (2011) Detection of beta cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci U S A 108:19018–19023CrossRef PubMed PubMedCentral
  26.Yang BT, Dayeh TA, Kirkpatrick CL et al (2011) Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia 54:360–367CrossRef PubMed PubMedCentral
  27.Brenet F, Moh M, Funk P et al (2011) DNA methylation of the first exon is tightly linked to transcriptional silencing. PLoS One 6:e14524CrossRef PubMed PubMedCentral
  28.Gilbert ER, Liu D (2012) Epigenetics: the missing link to understanding beta-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics 7:841–852CrossRef PubMed PubMedCentral
  29.Kim AY, Park YJ, Pan X et al (2015) Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun 6:7585CrossRef PubMed PubMedCentral
  30.Liu CC, Lin JH, Hsu TW et al (2015) IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation. Int J Cancer Journal international du cancer 136:547–559PubMed
  31.Li Y, Deuring J, Peppelenbosch MP, Kuipers EJ, de Haar C, van der Woude CJ (2012) IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer. Carcinogenesis 33:1889–1896CrossRef PubMed
  32.Cardenas H, Vieth E, Lee J et al (2014) TGF-beta induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells. Epigenetics 9:1461–1472CrossRef PubMed PubMedCentral
  33.Husseiny MI, Kuroda A, Kaye AN, Nair I, Kandeel F, Ferreri K (2012) Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes. PLoS One 7:e47942CrossRef PubMed PubMedCentral
  34.Husseiny MI, Kaye A, Zebadua E, Kandeel F, Ferreri K (2014) Tissue-specific methylation of human insulin gene and PCR assay for monitoring beta cell death. PLoS One 9:e94591CrossRef PubMed PubMedCentral
  
• 作者单位：Jinxiu Rui (1)
  Songyan Deng (1)
  Jasmin Lebastchi (1)
  Pamela L. Clark (1)
  Sahar Usmani-Brown (2)
  Kevan C. Herold (1) (3)
  
  1. Department of Immunobiology, Yale University, 300 George St, New Haven, CT, 06520, USA
  2. L2 Diagnostics, New Haven, CT, USA
  3. Department Internal Medicine, Yale University, New Haven, CT, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Type 1 diabetes is caused by the immunological destruction of pancreatic beta cells. Preclinical and clinical data indicate that there are changes in beta cell function at different stages of the disease, but the fate of beta cells has not been closely studied. We studied how immune factors affect the function and epigenetics of beta cells during disease progression and identified possible triggers of these changes.