Changes in Surface-Charge Density of Blood Cells After Sudden Unexpected Death

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• 作者：Joanna Kotyńska (1)
  Aneta D. Petelska (1) aneta@uwb.edu.pl
  Micha? Szeremeta (2)
  Anna Niemcunowicz-Janica (2)
  Zbigniew A. Figaszewski (13)
• 关键词：Erythrocytes – Microelectrophoresis – pH measurement – Sudden unexpected death – Surface charge density – Thrombocytes
• 刊名：Journal of Membrane Biology
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：245
• 期：4
• 页码：185-190
• 全文大小：346.0 KB
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• 作者单位：1. Institute of Chemistry, University of Bialystok, Al. J. Pilsudskiego 11/4, 15-443 Bialystok, Poland2. Department of Forensic Medicine, Medical University of Bialystok, Waszyngtona St. 13, 15-230 Bialystok, Poland3. Laboratory of Electrochemical Power Sources, Faculty of Chemistry, University of Warsaw, Pasteur St. 1, 02-093 Warsaw, Poland
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Human Physiology
  
• 出版者：Springer New York
• ISSN：1432-1424

文摘

The objective of the investigation was evaluation of postmortem changes of electric charge of human erythrocyte and thrombocyte membranes after sudden unexpected death. The surface charge density values were determined on the basis of the electrophoretic mobility measurements of the cells carried out at various pHs of electrolyte solution. The interactions between both erythrocyte and thrombocyte membranes and electrolyte ions were studied. Values of parameters characterizing the membrane—that is, the total surface concentrations of both acidic and basic groups and their association constants with solution ions—were calculated on the basis of a four-equilibria mathematical model. The model was validated by comparison of these values to experimental data. We established that examined electric properties of the cell membranes are affected by sudden unexpected death. Postmortem processes occurring in the cell membranes can lead to disorders of existing equilibria, which in turn result in changes in values of all the above-mentioned parameters.