Pituitary tumor-transforming gene-1 serves as an independent prognostic biomarker for gastric cancer

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• 作者：Mi-die Xu ; Lei Dong ; Peng Qi ; Wei-wei Weng ; Xiao-han Shen ; Shu-juan Ni…
• 关键词：Gastric cancer ; PTTG1 ; Immunohistochemistry ; Prognosis
• 刊名：Gastric Cancer
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：19
• 期：1
• 页码：107-115
• 全文大小：786 KB
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• 作者单位：Mi-die Xu (1) (2) (3)
  Lei Dong (1) (2) (3)
  Peng Qi (1) (2) (3)
  Wei-wei Weng (1) (2) (3)
  Xiao-han Shen (1) (2) (3)
  Shu-juan Ni (1) (2) (3)
  Dan Huang (1) (2) (3)
  Cong Tan (1) (2) (3)
  Wei-qi Sheng (1) (2) (3)
  Xiao-yan Zhou (1) (2) (3)
  Xiang Du (1) (2) (3) (4)
  
  1. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China
  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China
  3. Institute of Pathology, Fudan University, Shanghai, 200032, China
  4. Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Gastroenterology
  Surgical Oncology
  Pathology
  Radiotherapy
  
• 出版者：Springer Japan
• ISSN：1436-3305

文摘

Background Pituitary tumor-transforming gene-1 (PTTG1) is a transcription factor that can affect transcriptional activity, angiogenesis, and cell senescence. We examined PTTG1 mRNA and protein expression in gastric cancer (GC) cell lines and tissues to determine its value as a biomarker for GC diagnosis and therapy.