Dextran gadolinium complex containing folate groups as a potential magnetic resonance imaging contrast agent

详细信息    查看全文

• 作者：Hui-juan Du ; Yan-chun Shen ; Yu-ping Liu ; Lin Han…
• 关键词：Magnetic resonance imaging (MRI) ; Contrast agent ; Tumor ; targeting ; Dextran ; Diethylenetriamine ; pentaacetic acid (DTPA) ; Folic acid (FA)
• 刊名：Chinese Journal of Polymer Science
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：33
• 期：9
• 页码：1325-1333
• 全文大小：639 KB
• 参考文献：1.Lauterbur, P.C., Nature, 1973, 242: 190View Article
  2.Wedeking, P., Sotak, C.H., Telser, J., Kumar, K., Chang, C.A. and Tweedle, M.F., Magn. Reson. Imaging, 1992, 10: 97View Article
  3.Gong, F.M., Zhang, Z.Q., Chen, X.D., Zhang, L., Yu, X.S., Yang, Q.H., Shuai, X.T., Liang, B.L. and Cheng, D., Chinese J. Polym. Sci., 2014, 32(3): 321View Article
  4.Villaraza, A.J.L., Bumb, A. and Brechbiel, M.W., Chem. Rev., 2010, 110: 2921View Article
  5.Yan, G.P., Ai, C.W., Zong, R.F. and Liu, F., Chin. Sci. Bull., 2001, 55(27鈥?8): 3085
  6.Yan, G.P., Hu, B., Liu, M.L. and Li, L.Y., J. Pharm. Pharmacol., 2005, 57(3): 351View Article
  7.Yan, G.P., Zhuo, R.X., Zhang, X., Xu, M.Y., Li, L.Y. and Ye, Z.H., Polym. Int., 2002, 51: 892View Article
  8.Comblin, V., Gilsoul, D., Hermann, M., Humblet, V. and Jacques, V., Coord. Chem. Rev., 1999, 185: 451View Article
  9.Weinmann, H.J., Brash, R.C., Press, W.R. and Wesby, G.E., Radiology, 1984, 142: 619
  10.Wen, J., Zhuo, R.X. and Wang, L., Chin. J. Magn. Reson., 1998, 15(3): 217
  11.Driksen, A., Langereis, S., de Waal, B.F.M., van Genderen, M.H.P., Meijer, E.W., de Lussanet, Q.G. and Hackeng, T.M., Org. Lett., 2004, 6(26): 4857View Article
  12.Bligh, S.W.A., Chowdhury, A.S., Kennedy, D., Luchinat, C. and Parigi, G., Magn. Reson. Med., 1999, 41: 767View Article
  13.Yan, G.P. and Zhuo, R.X., Chin. Sci. Bull., 2001, 46(15): 1233View Article
  14.Zhou, X., Yang, L., Yan, G.P., Xu, W., Zhou, C.K., Zhang, Q., Li, L., Liu, F., Guo, J.F. and Zhao, Q., J. Rare Earths, 2012, 30(9): 884View Article
  15.Jung, K.H., Kim, H.K., Lee, G.H., Kang, D.S., Park, J.A., Kim, K.M., Chang, Y.M. and Kim, T.J., J. Med. Chem., 2011, 54(15): 5385View Article
  16.Jain, T.K., Foy, S.P., Erokwu, B., Dimitrijevic, S., Flask, C.A. and Labhasetwar, V., Biomaterials, 2009, 30: 6748View Article
  17.Wi, X.M., Feng, Y., Jeong, E.K., Mohs, A.M., Emerson, L. and Lu, Z.R., Pharm. Res., 2009, 26: 2202View Article
  18.Yu, K.C., Hu, H.B., Liu, M.L., Yuan, H.Z., Ye, C.H. and Zhuo, R.X., Chinese J. Polym. Sci., 1999, 17(5): 471
  19.Yan, G.P., Zhuo, R.X., Yang, Y.H., Xu, M.Y., Li, L.Y. and Ye, Z.H., J. Bioact. Compatible Polym., 2002, 17(2): 139View Article
  20.Lauffer, R.B., Chem. Rev., 1987, 87: 901View Article
  21.Caravan, P., Ellison, J.J., Mcmurry, T.J. and Lauffer, R.B., Chem. Rev., 1999, 99: 2293View Article
  22.Kobayashi, H., Kawamoto, S., Star, R.A., Waldmann, T.A., Tagaya, Y. and Brechbiel, M.W., Cancer Res., 2006, 63(2): 271
  23.Yan, G.P., Bottle, S.E., Zhuo, R.X., Wei, L., Liu, M.L. and Li, L.Y., J. Bioact. Compatible Polym., 2004, 19(6): 453View Article
  24.Yan, G.P., Li, Z., Xu, W., Zhang, Q., Li, L., Liu, F., Han, L., Ge, Y.X. and Guo, J.F., Int. J. Pharmaceut., 2011, 407: 119View Article
  25.Rinaudo, M., Polym. Int., 2008, 57(3): 397View Article
  26.Yan, G.P., Xu, W., Yang, L., Li, L., Liu, F. and Guo, Q.Z., Pharm. Res., 2010, 27(9): 1884View Article
  27.Sega, E.I. and Low, P.S., Cancer Metastasis Rev., 2008, 27: 655View Article
  28.Sun, X.M., Xu, J.X., Tang, J.B., Sui, M.H. and Shen, Y.Q., Chinese J. Polym. Sci., 2011, 29(4): 427View Article
  29.Leamon, C.P., Curr. Opin. Invest. Drugs, 2008. 9(12): 1277
  30.Leamon, C.P., Cooper, S.R. and Hardee, G.E., Bioconjugate Chem., 2003, 14: 738View Article
  31.Majoros, I.J., Williams, C.R, Becker, A. and Baker, J.R.Jr., WIREs Nanomed. Nanobiotechnol., 2009, 502鈥?10.
  32.Shukla, S., Wu, G., Chatterjee, M., Yang, W., Sekido, M., Diop, L.A., Muller, R., Sudimack, J.J., Lee, R.J., Barth, R.F. and Tjarks, W., Bioconjugate Chem., 2003, 14: 158View Article
  33.Kyung, M.W., Lin, Y.H., O鈥橪oughlin, T., Tang, Y., Kim, D.E., Weissleder, R. and Tung, C.H., Bioconjugate Chem., 2003, 14: 539View Article
  34.Konda, S.D., Aref, M., Wang, S., Brechbiel, M. and Wiener, E.C., Magn. Reson. Mater. Phys., Biol. Med., 2001, 12: 104View Article
  35.Yan, G.P., Liu, M.L. and Li, L.Y., Bioconjugate Chem., 2005, 16: 967View Article
  36.Yan, G.P., Shao, C.T., Han, L., Zou, T.J., Liu, F., Gong, X.Y. and Chang, X.P., Journal of Wuhan Institute of Technology, 2013, 7: 43
  37.Shi, F.Q., Medical animal experiment method, Beijing: People鈥檚 Medical Publishing House, China, 1990
  
• 作者单位：Hui-juan Du (1)
  Yan-chun Shen (1)
  Yu-ping Liu (1)
  Lin Han (1)
  Yao Zheng (1)
  Guo-ping Yan 閯㈠浗骞?/a> (1)
  Yuan-yuan Tu (1)
  Jiang-yu Wu (1)
  Qing-zhong Guo (1)
  Yun-fei Zhang (1)
  Xiao-tian Xia (2)
  Xiao-li Lan (2)
  Yong-xue Zhang (2)
  
  1. School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan, 430074, China
  2. Center for PET of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Condensed Matter Physics
  Industrial Chemistry and Chemical Engineering
  Polymer Sciences
  Characterization and Evaluation of Materials
  
• 出版者：Chinese Chemical Society and Institute of Chemistry, CAS, co-published with Springer
• ISSN：1439-6203

文摘

Folate-containing dextran ligand (FA-Dextran-DTPA) was synthesized by the incorporation of diethylenetriaminepentaacetic acid (DTPA) and folate (FA) as a tumor-targeting group into dextran as a polymer carrier. This ligand was further reacted with gadolinium chloride to make a dextran gadolinium complex FA-Dextran-DTPA-Gd. The ligand and its gadolinium complex were characterized by 1H-NMR, FTIR, UV-Vis, average particle sizes and zeta potential, as well. In vitro properties including relaxivity, cytotoxicity assay, cellular uptake assay, and magnetic resonance imaging (MRI) were also evaluated. Compared with Gd-DTPA, FA-Dextran-DTPA-Gd possessed obviously higher relaxation effectiveness and lower cytotoxicity to HeLa cells. FA-Dextran-DTPA-Gd had a high affinity to the H460 and MDA-MB-231 tumor cells and can be taken up selectively by these tumor cells. Moreover, FA-Dextran-DTPA-Gd showed enhanced signal intensities (SI) of MRI and enhanced the contrast of MR images of tumor cells. These results indicated that FA-Dextran-DTPA-Gd showed the potential as a tumor-targeting contrast agent in MRI.