Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese
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- 作者：Yun Qian (6) (7)
Sijun Liu (6)
Feng Lu (6) (7)
Huizhang Li (6) (6)
Meihua Dong (7)
Yudi Lin (7)
Jiangbo Du (6)
Yuan Lin (6)
Jianhang Gong (6)
Guangfu Jin (6)
Juncheng Dai (6)
Zhibin Hu (6) (7)
Hongbing Shen (6) (7) - 关键词：Fat mass and obesity ; associated Gene ; Genome ; wide association study ; Genetic susceptibility ; Single nucleotide polymorphism ; Type 2 diabetes
- 刊名：BMC Genetics
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：14
- 期：1
- 全文大小：183 KB
- 参考文献：1. Narayan KM, Boyle JP, Geiss LS, Saaddine JB, Thompson TJ: Impact of recent increase in incidence on future diabetes burden: US, 2005-050. / Diabetes Care 2006,29(9):2114-116. CrossRef
2. Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, Hu FB: Diabetes in Asia: epidemiology, risk factors, and pathophysiology. / JAMA 2009,301(20):2129-140. CrossRef
3. Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H, Ji Q, Zhu D, Ge J, Lin L, Chen L, Guo X, Zhao Z, Li Q, Zhou Z, Shan G, He J, China National Diabetes and Metabolic Disorders Study Group: Prevalence of diabetes among men and women in China. / N Engl J Med 2010,362(12):1090-101. CrossRef
4. Stumvoll M, Goldstein BJ, van Haeften TW: Type 2 diabetes: principles of pathogenesis and therapy. / Lancet 2005,365(9467):1333-346. CrossRef
5. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, / et al.: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. / Science 2007,316(5829):1341-345. CrossRef
6. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, McCarthy MI, Hattersley AT, Wellcome Trust Case Control Consortium (WTCCC): Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. / Science 2007,316(5829):1336-341. CrossRef
7. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, / et al.: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. / Science 2007,316(5826):889-94. CrossRef
8. Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, Froguel P, Kadowaki T: Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. / Diabetologia 2007,50(12):2461-466. CrossRef
9. Ng MC, Park KS, Oh B, Tam CH, Cho YM, Shin HD, Lam VK, Ma RC, So WY, Cho YS, Kim HL, Lee HK, Chan JC, Cho NH: Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. / Diabetes 2008,57(8):2226-233. CrossRef
10. Hu C, Zhang R, Wang C, Wang J, Ma X, Lu J, Qin W, Hou X, Wang C, Bao Y, Xiang K, Jia W: PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. / PLoS One 2009,4(10):e7643. CrossRef
11. Han X, Luo Y, Ren Q, Zhang X, Wang F, Sun X, Zhou X, Ji L: Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. / BMC Med Gene 2010, 11:81. CrossRef
12. Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Nakamura Y, Maeda S: Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. / Diabetes 2008,57(3):791-95. CrossRef
13. Li H, Wu Y, Loos RJ, Hu FB, Liu Y, Wang J, Yu Z, Lin X: Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. / Diabetes 2008,57(1):264-68. CrossRef
14. Liu Y, Liu Z, Song Y, Zhou D, Zhang D, Zhao T, Chen Z, Yu L, Yang Y, Feng G, Li J, Zhang J, Liu S, Zhang Z, He L, Xu H: Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. / Obesity (Silver Spring) 2010,18(8):1619-624. CrossRef
15. Lee YH, Kang ES, Kim SH, Han SJ, Kim CH, Kim HJ, Ahn CW, Cha BS, Nam M, Nam CM, Lee HC: Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. / J Hum Genet 2008,53(11-2):991-98. CrossRef
16. Song Y, You NC, Hsu YH, Howard BV, Langer RD, Manson JE, Nathan L, Niu T, Tinker FL, Liu S: FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women. / Obesity (Silver Spring) 2008,16(11):2472-480. CrossRef
17. Wen J, R?nn T, Olsson A, Yang Z, Lu B, Du Y, Groop L, Ling C, Hu R: Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. / PLoS One 2010,5(2):e9153. CrossRef
18. Li H, Kilpel?inen TO, Liu C, Zhu J, Liu Y, Hu C, Yang Z, Zhang W, Bao W, Cha S, Wu Y, Yang T, Sekine A, Choi BY, Yajnik CS, Zhou D, Takeuchi F, Yamamoto K, Chan JC, Mani KR, Been LF, Imamura M, Nakashima E, Lee N, Fujisawa T, Karasawa S, Wen W, Joglekar CV, Lu W, Chang Y, / et al.: Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. / Diabetologia 2012,55(4):981-95. CrossRef
19. Hertel JK, Johansson S, Sonestedt E, Jonsson A, Lie RT, Platou CG, Nilsson PM, Rukh G, Midthjell K, Hveem K, Melander O, Groop L, Lyssenko V, Molven A, Orho-Melander M, Nj?lstad PR: FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. / Diabetes 2011,60(5):1637-644. CrossRef
20. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O’Rahilly S, Schofield CJ: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. / Science 2007,318(5855):1469-472. CrossRef
21. Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J: FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. / Diabetes 2011,60(1):258-68. CrossRef
22. Lu F, Qian Y, Li H, Dong M, Lin Y, Du J, Lin Y, Chen J, Shen C, Jin G, Dai J, Hu Z, Shen H: Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case–control study in Han Chinese. / J Hum Genet 2012,57(5):320-25. CrossRef
23. Qian Y, Lu F, Dong M, Lin Y, Li H, Chen J, Shen C, Jin G, Hu Z, Shen H: Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population. / PLoS One 2012,7(4):e35060. CrossRef
24. Zhou BF, Cooperative Meta-Analysis Group of the Working Group on Obesity in China: Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. / Biomed Environ Sci 2002,15(1):83-6. - 作者单位：Yun Qian (6) (7)
Sijun Liu (6)
Feng Lu (6) (7)
Huizhang Li (6) (6)
Meihua Dong (7)
Yudi Lin (7)
Jiangbo Du (6)
Yuan Lin (6)
Jianhang Gong (6)
Guangfu Jin (6)
Juncheng Dai (6)
Zhibin Hu (6) (7)
Hongbing Shen (6) (7)
6. Department of Cancer Prevention and Treatment, Zhejiang Cancer Hospital, Hangzhou, China
7. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China - ISSN：1471-2156
文摘
Background Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case–control study with 2,925 T2D patients and 3,281 controls in Han Chinese. Results Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95% confidence interval (95% CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95% CI = 1.07-1.19). Conclusions Our findings indicate that the genetic variant in FTO may contribute to T2D risk in Han Chinese and rs8050136 polymorphism may be a genetic marker for T2D susceptibility.