The Report of Sustained Low-Efficiency Dialysis (SLED) Treatment in Fifteen Patients of Severe Snakebite

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• 作者：Junzhang Cheng (1)
  Dan Wang (1)
  Shouliang Hu (1)
  Hong Jiang (1)
  Hongzhu Lu (1)
  Qingfeng Lei (1)
  Juncheng Liu (1)
  Fanli Yuan (1)
  Rong Chen (1)
  
• 关键词：Sustained low ; efficiency dialysis ; Snakebite ; Effectiveness
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：69
• 期：1
• 页码：71-74
• 全文大小：182 KB
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• 作者单位：Junzhang Cheng (1)
  Dan Wang (1)
  Shouliang Hu (1)
  Hong Jiang (1)
  Hongzhu Lu (1)
  Qingfeng Lei (1)
  Juncheng Liu (1)
  Fanli Yuan (1)
  Rong Chen (1)
  
  1. Department of Nephrology, The First Hospital of JingZhou, Yangtze University, Hangkongstreet 8, Jingzhou, 434000, Hubei, China
  
• ISSN：1559-0283

文摘

To investigate the therapeutic efficacy of sustained low-efficiency dialysis (SLED) in severe snakebite patients. Fifteen patients of severe snakebite was treated with SLED from July 2005 to August 2009 were included in the study. Central venous access was established in all patients. SLED was administered using Dialog+ dialyzer (B. Braun, Germany). SLED sessions were 6-2?h in duration at a blood flow rate of 200?ml/min and a dialysate flow rate of 300?ml/min. Heparin or low molecular weight heparin was used as anticoagulant. Biochemical indicators, APACHE II scores before and after SLED, and clinical outcomes were evaluated. The levels of serum creatinine, glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, creatine kinase isozyme MB, and creatine kinase were significantly lower than the level before SLED (P?<?0.05); the level of cholinesterase was significantly higher after SLED (P?<?0.01); the APACHE II score before SLED was 14.1?±?3.8, but decreased significantly to 7.9?±?1.4, 6.2?±?1.1, and 4.2?±?0.8 on days 1, 2, and 7 after SLED, respectively (P?<?0.01). Three patients died on days 1, 3, and 4 after SLED, respectively. The remaining twelve patients were either cured or showed improvement at the time of discharge. The survival rate was 80?% where as mortality was 20?%. SLED may be an effective treatment option in severe snakebite patients. It can reduce mortality, thereby, resulting in increased survival rates.