Combined effect of BCG vaccination and enriched environment promote neurogenesis and spatial cognition via a shift in meningeal macrophage M2 polarization
详细信息 查看全文
- 作者：Fangfang Qi ; Zejie Zuo ; Junhua Yang ; Saisai Hu ; Yang Yang…
- 关键词：Enriched environment ; Vaccine ; Th1/Th2 balance ; Hippocampus ; Neurotrophins ; Cytokine
- 刊名：Journal of Neuroinflammation
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：3719KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
- 卷排序：14
文摘
BackgroundThe spatial learning abilities of developing mice benefit from extrinsic cues, such as an enriched environment, with concomitant enhancement in cognitive functions. Interestingly, such enhancements can be further increased through intrinsic Bacillus Calmette-Guérin (BCG) vaccination.