Chronic Phencyclidine Induces Inflammatory Responses and Activates GSK3β in Mice
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- 作者：Shenghua Zhu (1)
Hongxing Wang (2)
Ruoyang Shi (3)
Ruiguo Zhang (4)
Junhui Wang (5)
Lynda Kong (6)
Yingxia Sun (7)
Jue He (8)
Jiming Kong (3)
Jun-Feng Wang (1)
Xin-Min Li (9) - 关键词：Phencyclidine ; Prepulse inhibition ; Astrocytes ; Microglia ; Neuroinflammation ; Glycogen synthase kinase ; 3β
- 刊名：Neurochemical Research
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：39
- 期：12
- 页码：2385-2393
- 全文大小：913 KB
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Hongxing Wang (2)
Ruoyang Shi (3)
Ruiguo Zhang (4)
Junhui Wang (5)
Lynda Kong (6)
Yingxia Sun (7)
Jue He (8)
Jiming Kong (3)
Jun-Feng Wang (1)
Xin-Min Li (9)
1. Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, MB, R3E 0T6, Canada
2. Department of Clinical Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, People’s Republic of China
3. Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada
4. Department of Psychosomatic Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, People’s Republic of China
5. Mental Health Center, Shantou University, Shantou, 515063, Guangdong, People’s Republic of China
6. Department of Psychiatry, Faculty of Medicine, University of Manitoba, Winnipeg, MB, R3E 3N4, Canada
7. Institute of Acumox and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China
8. The First Hospital Affiliated to Henan University, Henan University, Kaifeng, 475001, Henan, People’s Republic of China
9. Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, T6G 2B7, Canada - ISSN：1573-6903
文摘
Use of phencyclidine (PCP) in rodents can mimic some aspects of schizophrenia. However, the underlying mechanism is still unclear. Growing evidence indicates that neuroinflammation plays a significant role in the pathophysiology of schizophrenia. In this study, we focused on inflammatory responses as target of PCP for inducing schizophrenia-like symptoms. 3-month-old C57BL/6J mice received daily injections of PCP (20?mg/kg, i.p.) or saline for one week. PCP-injected mice produced schizophrenia-like behaviours including impaired spatial short-term memory assessed by the Y-maze task and sensorimotor gating deficits in a prepulse inhibition task. Simultaneously, chronic PCP administration induced astrocyte and microglial activation in both the cortex and hippocampus. Additionally, the proinflammatory cytokine interleukin-1β was significantly up-regulated in PCP administrated mice. Furthermore, PCP treatment decreased ratio of the phospho-Ser9 epitope of glycogen synthase kinase-3β (GSK3β) over total GSK3β, which is indicative of increased GSK3β activity. These data demonstrate that chronic PCP in mouse produces inflammatory responses and GSK3β activation.