Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers

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• 作者：Xin Song (1)
  Yongguang Tao (1)
  Liang Zeng (1)
  Jing Yang (1)
  Faqing Tang (1)
  Leo M. Lee (2)
  Jianping Gong (3)
  Qiao Wu (4)
  Ya Cao (1)
  
• 关键词：latent membrane protein1 ; c ; Jun ; Jun B ; heterodimer ; cyclin D1 ; cell cycle
• 刊名：Science China Life Sciences
• 出版年：2005
• 出版时间：July 2005
• 年：2005
• 卷：48
• 期：4
• 页码：385-393
• 全文大小：1180KB
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• 作者单位：Xin Song (1)
  Yongguang Tao (1)
  Liang Zeng (1)
  Jing Yang (1)
  Faqing Tang (1)
  Leo M. Lee (2)
  Jianping Gong (3)
  Qiao Wu (4)
  Ya Cao (1)
  
  1. Cancer Research Institute, Xiangya School of Medicine, Central South University, 410078, Changsha, China
  2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute, P.O. Box B, 21702, Frederick, MD, USA
  3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, 430030, Wuhan, China
  4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, 361005, Xiamen, China
  

文摘

In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cyclinD1 accelerated the progression of cell cycle.