Emergence of reticuloendotheliosis virus in pigeons in Guangdong Province, Southern China
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- 作者：Shao-Lun Zhai ; Sheng-Nan Chen ; Tao Lin ; Xiao-Hui Wen ; Wen-Kang Wei…
- 刊名：Archives of Virology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：161
- 期：7
- 页码：2007-2011
- 全文大小：1,165 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Virology
Medical Microbiology
Infectious Diseases - 出版者：Springer Wien
- ISSN：1432-8798
- 卷排序：161
文摘
Reticuloendotheliosis virus (REV), an important immunosuppressive pathogen, has many hosts, including chickens, ducks, geese, turkeys, and wild birds. Clinically, REV may lead to increased susceptibility to other pathogens, resulting in serious tissue damage (especially tumors) and the death of its host. In this study, we encountered a disease outbreak resulting in a large number of deaths of pigeons in Guangdong Province, Southern China. Histopathological analysis revealed apparent tumor-like lesions in multiple organs of pigeons. PCR assays for detection of tumor-associated pathogens (REV, avian leukosis virus, and Marek’s disease virus) in poultry revealed the presence of REV sequences only. Moreover, fowlpox virus (FPV) with an insertion of REV long terminal repeat (LTR) sequences was also considered, but it was excluded using a specific PCR assay. To gain more genetic information, two full-length REV genome sequences were determined and found to have the highest nucleotide sequence similarity (99.9 %) and the closest genetic relationship to a vaccine strain (MD-2) and had a more distant genetic relationship (94.3 %) to a duck-origin strain (ATCC-VR775). To confirm the presence of REVs in pigeons, specific-pathogen-free (SPF) chickens and healthy pigeons were inoculated with microfiltered tumor tissue homogenates and were found to be susceptible to infection with REV. To our knowledge, this is the first report of REV in pigeons, and the data suggest that pigeons may be the natural host of REV.KeywordsReticuloendotheliosisReticuloendotheliosis virusFirst reportPigeonsSouth China