Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation

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• 作者：Yongxia Cai ; Yanbo Shen ; Lili Gao ; Minmin Chen ; Min Xiao…
• 关键词：Acute pancreatitis ; Karyopherin alpha 2 (KPNA2) ; NF ; κB ; AR42J cells ; Inflammation ; Cerulein
• 刊名：Digestive Diseases and Sciences
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：61
• 期：3
• 页码：747-757
• 全文大小：4,922 KB
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• 作者单位：Yongxia Cai (1) (2)
  Yanbo Shen (1) (2)
  Lili Gao (1) (2)
  Minmin Chen (1) (2)
  Min Xiao (3)
  Zhongwei Huang (1) (2)
  Dongmei Zhang (2) (4)
  
  1. Department of Emergency, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China
  2. Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China
  3. National Glycoengineering Research Center, State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People’s Republic of China
  4. Department of Pathogen Biology, Medical College, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

Background Activation of the transcription factor NF-κB and expression of pro-inflammatory mediators have been considered as major events of acute pancreatitis (AP). Karyopherin alpha 2 (KPNA2), a member of the importin α family, reportedly modulates p65 subcellular localization.