A mindfulness-based stress management program and treatment with omega-3 fatty acids to maintain a healthy mental state in hospital nurses (Happy Nurse Project): study protocol for a randomized controlled trial

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• 作者：Norio Watanabe (1)
  Toshi A Furukawa (2)
  Masaru Horikoshi (3)
  Fujika Katsuki (4)
  Tomomi Narisawa (1)
  Mie Kumachi (5)
  Yuki Oe (3)
  Issei Shinmei (3)
  Hiroko Noguchi (6)
  Kei Hamazaki (7)
  Yutaka Matsuoka (1)
  
  1. Department of Clinical Epidemiology ; Translational Medical Center ; National Center of Neurology and Psychiatry ; 4-1-1 Ogawa-higashi ; Kodaira ; Tokyo ; Tokyo 187-8551 ; Japan
  2. Departments of Health Promotion and Human Behavior and of Clinical Epidemiology ; Kyoto University Graduate School of Medicine/School of Public Health ; Yoshida Konoe-cho ; Sakyo-ku ; Kyoto ; 606-8501 ; Japan
  3. National Center for Cognitive Behavior Therapy and Research ; National Center of Neurology and Psychiatry ; 4-1-1 Ogawa-higashi ; Kodaira ; Tokyo ; 187-8551 ; Japan
  4. Department of Psychiatric and Mental Health Nursing ; Nagoya City University School of Nursing ; 1 Kawasumi ; Mizuho-ku ; Nagoya ; 467-0001 ; Japan
  5. Department of Clinical Research ; Translational Medical Center ; National Center of Neurology and Psychiatry ; 4-1-1 Ogawa-higashi ; Kodaira ; Tokyo ; Japan
  6. Correspondence Division ; Musashino University ; 1-1-20 Shinmachi ; Nishitokyo ; Tokyo ; 202-8585 ; Japan
  7. Department of Public Health ; Faculty of Medicine ; University of Toyama ; 2630 Sugitani ; Toyama ; 930-0194 ; Japan
  
• 关键词：Anxiety ; Behavior therapy ; Depression ; Fatty acids ; Omega ; 3 ; Mindfulness ; Prevention and control
• 刊名：Trials
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：16
• 期：1
• 全文大小：758 KB
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• 刊物主题：Medicine/Public Health, general; Biomedicine general; Statistics for Life Sciences, Medicine, Health Sciences;
• 出版者：BioMed Central
• ISSN：1745-6215

文摘

Background It is reported that nursing is one of the most vulnerable jobs for developing depression. While they may not be clinically diagnosed as depressed, nurses often suffer from depression and anxiety symptoms, which can lead to a low level of patient care. However, there is no rigorous evidence base for determining an effective prevention strategy for these symptoms in nurses. After reviewing previous literature, we chose a strategy of treatment with omega-3 fatty acids and a mindfulness-based stress management program for this purpose. We aim to explore the effectiveness of these intervention options for junior nurses working in hospital wards in Japan. Methods/Design A factorial-design multi-center randomized trial is currently being conducted. A total of 120 nurses without a managerial position, who work for general hospitals and gave informed consent, have been randomly allocated to a stress management program or psychoeducation using a leaflet, and to omega-3 fatty acids or identical placebo pills. The stress management program has been developed according to mindfulness cognitive therapy and consists of four 30-minute individual sessions conducted using a detailed manual. These sessions are conducted by nurses with a managerial position. Participants allocated to the omega-3 fatty acid groups are provided with 1,200 mg/day of eicosapentaenoic acid and 600 mg/day of docosahexaenoic acid for 90 days. The primary outcome is the change in the total score of the Hospital Anxiety and Depression Scale (HADS), determined by a blinded rater via the telephone at week 26. Secondary outcomes include the change in HADS score at 13 and 52 weeks; presence of a major depressive episode; severity of depression, anxiety, insomnia, burnout, and presenteeism; utility scores and adverse events at 13, 26 and 52 weeks. Discussion An effective preventive intervention may not only lead to the maintenance of a healthy mental state in nurses, but also to better quality of care for inpatients. This paper outlines the background and methods of a randomized trial that evaluates the possible additive value of omega-3 fatty acids and a mindfulness-based stress management program for reducing depression in nurses. Trial registration Clinicaltrials.gov: NCT02151162 (registered on 27 May 2014).