Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4

详细信息    查看全文

• 作者：Max Leenders (1) (2)
  Samsiddhi Bhattacharjee (3)
  Paolo Vineis (1) (4)
  Victoria Stevens (5)
  H. Bas Bueno-de-Mesquita (2) (6)
  Xiao-Ou Shu (7)
  Laufey Amundadottir (3) (8)
  Myron Gross (9)
  Geoffrey S. Tobias (3)
  Jean Wactawski-Wende (10)
  Alan A. Arslan (11) (12) (13)
  Eric J. Duell (14)
  Charles S. Fuchs (15) (16)
  Steven Gallinger (17)
  Patricia Hartge (3)
  Robert N. Hoover (3)
  Elizabeth A. Holly (18)
  Eric J. Jacobs (19)
  Alison P. Klein (20) (21)
  Charles Kooperberg (22)
  Andrea LaCroix (5)
  Donghui Li (23)
  Margaret T. Mandelson (22) (24)
  Sara H. Olson (25)
  Gloria Petersen (26)
  Harvey A. Risch (27)
  Kai Yu (3)
  Brian M. Wolpin (15) (16)
  Wei Zheng (7)
  Ilir Agalliu (28)
  Demetrius Albanes (3)
  Marie-Christine Boutron-Ruault (29)
  Paige M. Bracci (18)
  Julie E. Buring (30) (31)
  Federico Canzian (32)
  Kenneth Chang (33)
  Stephen J. Chanock (3) (8)
  Michelle Cotterchio (34) (35)
  J. Michael Gaziano (36) (37)
  Edward L. Giovanucci (16) (38) (39)
  Michael Goggins (40)
  G?ran Hallmans (41)
  Susan E. Hankinson (16) (38)
  Judith A. Hoffman-Bolton (42)
  David J. Hunter (16) (38)
  Amy Hutchinson (3) (43)
  Kevin B. Jacobs (3) (43) (44)
  Mazda Jenab (45)
  Kay-Tee Khaw (46)
  Peter Kraft (38) (47)
  Vittorio Krogh (48)
  Robert C. Kurtz (49)
  Robert R. McWilliams (50)
  Julie B. Mendelsohn (3)
  Alpa V. Patel (5)
  Kari G. Rabe (26)
  Elio Riboli (1)
  Anne Tj?nneland (51)
  Dimitrios Trichopoulos (38) (52)
  Jarmo Virtamo (53)
  Kala Visvanathan (42)
  Joanne W. Elena (54)
  Herbert Yu (27)
  Anne Zeleniuch-Jacquotte (12) (13)
  Rachael Z. Stolzenberg-Solomon (3)
  
• 关键词：Pancreatic cancer ; One ; carbon metabolism ; Polymorphisms ; Biomarkers ; Epidemiology
• 刊名：Cancer Causes and Control
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：24
• 期：3
• 页码：595-602
• 全文大小：175KB
• 参考文献：1. Ehrlich M (2002) DNA methylation in cancer: too much, but also too little. Oncogene 21(35):5400-413 CrossRef
  2. Tibbetts AS, Appling DR (2010) Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr 30:57-1 CrossRef
  3. Liu JJ, Ward RL (2010) Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer. Adv Genet 71:79-21 CrossRef
  4. Larsson SC, Orsini N, Wolk A (2010) Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. JAMA 303(11):1077-083 CrossRef
  5. Kim D-H, Smith-Warner SA, Spiegelman D et al (2010) Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer. Cancer Causes Control 21(11):1919-930 CrossRef
  6. Collin SM, Metcalfe C, Refsum H et al (2010) Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev 19(6):1632-642 CrossRef
  7. Larsson SC, Giovannucci E, Wolk A (2007) Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 99(1):64-6 CrossRef
  8. Kim YI (1999) Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 10(2):66-8 CrossRef
  9. Baghurst PA, McMichael AJ, Slavotinek AH, Baghurst KI, Boyle P, Walker AM (1991) A case-control study of diet and cancer of the pancreas. Am J Epidemiol 134(2):167-79
  10. Bravi F, Polesel J, Bosetti C et al (2011) Dietary intake of selected micronutrients and the risk of pancreatic cancer: an Italian case-control study. Ann Oncol 22(1):202-06 CrossRef
  11. Gong Z, Holly EA, Bracci PM (2009) Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study. Cancer Causes Control 20(8):1317-325 CrossRef
  12. Larsson SC, H?kansson N, Giovannucci E, Wolk A (2006) Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men. J Natl Cancer Inst 98(6):407-13 CrossRef
  13. Oaks BM, Dodd KW, Meinhold CL, Jiao L, Church TR, Stolzenberg-Solomon RZ (2010) Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr 91(2):449-55 CrossRef
  14. Stolzenberg-Solomon RZ, Pietinen P, Barrett MJ, Taylor PR, Virtamo J, Albanes D (2001) Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers. Am J Epidemiol 153(7):680-87 CrossRef
  15. Silverman DT, Swanson CA, Gridley G et al (1998) Dietary and nutritional factors and pancreatic cancer: a case–control study based on direct interviews. J Natl Cancer Inst 90(22):1710-719 CrossRef
  16. Keszei AP, Verhage BAJ, Heinen MM, Goldbohm RA, van den Brandt PA (2009) Dietary folate and folate vitamers and the risk of pancreatic cancer in the Netherlands cohort study. Cancer Epidemiol Biomarkers Prev 18(6):1785-791 CrossRef
  17. Larsson SC, Giovannucci E, Wolk A (2006) Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology 131(4):1271-283 CrossRef
  18. Ohnami S, Sato Y, Yoshimura K et al (2008) His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk. Gastroenterology 135(2):477-88 CrossRef
  19. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ et al (2009) Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 41(9):986-90 CrossRef
  20. Diergaarde B, Brand R, Lamb J et al (2010) Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis. Pancreatology 10(2-):194-00 CrossRef
  21. Low S-K, Kuchiba A, Zembutsu H et al (2010) Genome-wide association study of pancreatic cancer in Japanese population. PLoS ONE 5(7):e11824 CrossRef
  22. Petersen GM, Amundadottir L, Fuchs CS et al (2010) A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 42(3):224-28 CrossRef
  23. Willis JA, Olson SH, Orlow I et al (2012) A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival. Clin Cancer Res 18(14):3942-951 CrossRef
  24. Wu C, Miao X, Huang L et al (2012) Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet 44(1):62-6 CrossRef
  25. Tanaka T, Scheet P, Giusti B et al (2009) Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet 84(4):477-82 CrossRef
  26. Lange LA, Croteau-Chonka DC, Marvelle AF et al (2010) Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults. Hum Mol Genet 19(10):2050-058 CrossRef
  27. Hazra A, Kraft P, Lazarus R et al (2009) Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet 18(23):4677-687 CrossRef
  28. Midttun ?, Hustad S, Ueland PM (2009) Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 23(9):1371-379 CrossRef
  29. Westfall PH, Young SS (1993) Resampling-based multiple testing: examples and methods for p-value adjustment. Wiley, New York, NY
  30. Yu K, Li Q, Bergen AW et al (2009) Pathway analysis by adaptive combination of P-values. Genet Epidemiol 33(8):700-09 CrossRef
  31. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57(1):289-00
  32. Chuang S-C, Stolzenberg-Solomon R, Ueland PM et al (2011) A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Eur J Cancer 47(12):1808-816 CrossRef
  
• 作者单位：Max Leenders (1) (2)
  Samsiddhi Bhattacharjee (3)
  Paolo Vineis (1) (4)
  Victoria Stevens (5)
  H. Bas Bueno-de-Mesquita (2) (6)
  Xiao-Ou Shu (7)
  Laufey Amundadottir (3) (8)
  Myron Gross (9)
  Geoffrey S. Tobias (3)
  Jean Wactawski-Wende (10)
  Alan A. Arslan (11) (12) (13)
  Eric J. Duell (14)
  Charles S. Fuchs (15) (16)
  Steven Gallinger (17)
  Patricia Hartge (3)
  Robert N. Hoover (3)
  Elizabeth A. Holly (18)
  Eric J. Jacobs (19)
  Alison P. Klein (20) (21)
  Charles Kooperberg (22)
  Andrea LaCroix (5)
  Donghui Li (23)
  Margaret T. Mandelson (22) (24)
  Sara H. Olson (25)
  Gloria Petersen (26)
  Harvey A. Risch (27)
  Kai Yu (3)
  Brian M. Wolpin (15) (16)
  Wei Zheng (7)
  Ilir Agalliu (28)
  Demetrius Albanes (3)
  Marie-Christine Boutron-Ruault (29)
  Paige M. Bracci (18)
  Julie E. Buring (30) (31)
  Federico Canzian (32)
  Kenneth Chang (33)
  Stephen J. Chanock (3) (8)
  Michelle Cotterchio (34) (35)
  J. Michael Gaziano (36) (37)
  Edward L. Giovanucci (16) (38) (39)
  Michael Goggins (40)
  G?ran Hallmans (41)
  Susan E. Hankinson (16) (38)
  Judith A. Hoffman-Bolton (42)
  David J. Hunter (16) (38)
  Amy Hutchinson (3) (43)
  Kevin B. Jacobs (3) (43) (44)
  Mazda Jenab (45)
  Kay-Tee Khaw (46)
  Peter Kraft (38) (47)
  Vittorio Krogh (48)
  Robert C. Kurtz (49)
  Robert R. McWilliams (50)
  Julie B. Mendelsohn (3)
  Alpa V. Patel (5)
  Kari G. Rabe (26)
  Elio Riboli (1)
  Anne Tj?nneland (51)
  Dimitrios Trichopoulos (38) (52)
  Jarmo Virtamo (53)
  Kala Visvanathan (42)
  Joanne W. Elena (54)
  Herbert Yu (27)
  Anne Zeleniuch-Jacquotte (12) (13)
  Rachael Z. Stolzenberg-Solomon (3)
  
  1. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
  2. Department of Gastroenterology and Hepatology, University Medical Center Utrecht, F02.618, Postal Box 85500, 3508GA, Utrecht, The Netherlands
  3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
  4. HuGeF Foundation, Turin, Italy
  5. Department of Epidemiology, American Cancer Society, Atlanta, GA, USA
  6. National Institute for Public Health and the Environment, Bilthoven, The Netherlands
  7. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
  8. Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
  9. Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA
  10. Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
  11. Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA
  12. Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
  13. New York University Cancer Institute, New York, NY, USA
  14. Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
  15. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
  16. Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  17. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
  18. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
  19. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA
  20. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  21. Department of Epidemiology, Johns Hopkins Medical Institutions, The Bloomberg School of Public Heath, The Sol Goldman Pancreatic Research Center, Baltimore, MD, USA
  22. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
  23. Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  24. Group Health Center for Health Studies, Seattle, WA, USA
  25. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
  26. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
  27. Yale University School of Public Health, New Haven, CT, USA
  28. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
  29. INSERM, Institut Gustave-Roussy, Paris-Sud University, Villejuif, France
  30. Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  31. Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA, USA
  32. Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany
  33. Comprehensive Digestive Disease Center, University of California, Irvine Medical Center, Orange, CA, USA
  34. Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
  35. Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada
  36. Physicians-Health Study, Divisions of Aging, Cardiovascular Medicine, and Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  37. Veterans Affairs Boston Healthcare System, Massachusetts Veterans Epidemiology Research and Information Center, Boston, MA, USA
  38. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
  39. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
  40. Departments of Oncology, Pathology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  41. Department of Public Health and Clinical Medicine, Nutritional Research, Ume? University, Ume?, Sweden
  42. Department of Epidemiology, The Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
  43. Core Genotyping Facility, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA
  44. Bioinformed Consulting Services, Gaithersburg, MD, USA
  45. International Agency for Research on Cancer (IARC/WHO), Lyon, France
  46. Department of Public Health and Primary Care, Clinical Gerontology, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK
  47. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
  48. Nutritional Epidemiology Unit, Fondazione Istituto di Recovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy
  49. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
  50. Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA
  51. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
  52. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece
  53. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
  54. Division of Cancer Prevention and Population Control, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
  
• ISSN：1573-7225

文摘

Purpose The evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed. Methods Using biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (<0.02) were followed up in 2,323 cases and 2,340 controls from eight case–control studies (PanC4) that participated in PanScan2. The correlation of SNPs with metabolite levels was assessed for 649 controls from the European Prospective Investigation into Cancer and Nutrition. Results When both stages were combined, we observed suggestive associations with PanCa for rs10887710 (MAT1A) (OR 1.13, 95?%CI 1.04-.23), rs1552462 (SYT9) (OR 1.27, 95?%CI 1.02-.59), and rs7074891 (CUBN) (OR 1.91, 95?%CI 1.12-.26). After correcting for multiple comparisons, no significant associations were observed in either the first or second stage. The three suggested SNPs showed no correlations with one-carbon biomarkers. Conclusions This is the largest genetic study to date to examine the relation between germline variations in OCM-related genes polymorphisms and the risk of PanCa. Suggestive evidence for an association between polymorphisms and PanCa was observed among the cohort-nested studies, but this did not replicate in the case–control studies. Our results do not strongly support the hypothesis that genes related to OCM play a role in pancreatic carcinogenesis.