High Efficacy of Methotrexate in Patients with Recurrent Idiopathic Acute Anterior Uveitis: a Prospective Study

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• 作者：Artur Bachta ; Bartłomiej Kisiel&#8230
• 关键词：Uveitis ; Inflammation ; Immunotherapy ; Methotrexate
• 刊名：Archivum Immunologiae et Therapiae Experimentalis
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：65
• 期：1
• 页码：93-97
• 全文大小：
• 刊物主题：Immunology; Pharmacology/Toxicology;
• 出版者：Springer International Publishing
• ISSN：1661-4917
• 卷排序：65

文摘

To evaluate prospectively the efficacy of methotrexate (MTX) in the treatment of recurrent idiopathic acute anterior uveitis (RIAAU). Nineteen out of 22 RIAAU patients completed the study (two patients withdrew their consent shortly after study initiation, one patient discontinued after 4 weeks because of the adverse effects). All patients were treated with MTX in a starting dose of 15 mg/week, increased to target dose of 25 mg/week after 4 weeks. In patients taking systemic corticosteroids (CS) the dose was gradually tapered (by 2.5 mg every week) until discontinuation. The mean follow-up period was 3.3 years (19–59 months). Sixteen patients (84 %) remained flare-free on MTX therapy. In the remaining three patients the mean interval between flares increased from 4.8 to 18.3 months. Systemic CS were tapered off in all patients. The number of acute anterior uveitis flares in the whole cohort decreased from 2.12 to 0.11/patient-year (p < 0.0001). All flares observed on MTX therapy occurred in HLA-B27-positive patients. MTX dosed at 25 mg/week is highly effective in the treatment of RIAAU.